Leser-Trélat syndrome (LTS) is a rare cutaneous paraneoplastic syndrome that barely affects patients with head and neck cancer. Here we present a case of 58-years old male presented with skin manifestation consistent with a sign of Leser-Trélat. A close investigation of the patient revealed that he had a recurrent laryngeal squamous cell carcinoma. The described case is the fifth case of a Leser-Trélat syndrome with squamous cell carcinoma of the larynx and the sixth to be reported in the head and neck squamous cell carcinoma. Thus sudden development of paraneoplastic dermatoses is recurrently a forewarning progression of the malignancy