In saline sodic soil, salts tend to accumulation in the surface soil and may be affecting on soil properties. A laboratory experiment was conducted in soil columns to ameliorate the soil properties and reduce soluble salts by application of ‘‘pressmud” (PM), ‘‘gypsum by product” (G) singly and/or in combinations (PM+G) on the highly calcareous salinesodic soil (pH= 8.22, ECe= 48.5 dS/m, CaCO3 = 29.44% and ESP=22.14%). PM and G could supply Ca directly to the soil in order to replace excess Na from the exchange site or out of the soil profile by leaching irrigation process with good quality water. The treatments consist of (0, 2.5, 5 and 10% of soil weight), (0, 2.5 and 5 g/kg per air-dried soil weight) of PM and G, respectively individual or in PM+G. Untreated soil was used as a control (CTRL). All treatments were replicated three times. After one month of saturating soil columns, leaching processes were applied during six month using irrigation water. At the end of experiments, soil pH, electrical conductivity (ECe), cations and exchangeable sodium percentage (ESP) were determined in all soil treatments. Results of this study indicate that soil pH, ECe, and ESP were decreased with increasing rates of amendment as compared with CTRL. The ECe was reduced from 48.5 dS/m to 7.65 dS/m, ESP ranged from 6.55% to 13.43% as compared with 22.14% of CTRL. Concentrations of soluble cations Ca and Mg were increased in all soil treatments. The highest rates of PM+G caused the highest amounts of soluble Ca and Mg. On other hand, these rates had not significant effect in soluble K with exception of PM rates. In addition, soluble Na was reduced by increasing rates of treatments and the high reduction of soluble Na was observed when the highest amounts of PM+G was used. Based on the obtained results, it therefore could be suggested that applications of PM+G have higher influence on reduction of soil salinity and sodicity than single ones.