Recently, the attention was focused on bioactive peptides obtained from natural
sources and physiological significance of these substances in some diseases characterized by
chronic inflammation and tissue damage. Therefore, this experiment was conducted to
evaluate the role of bradykinin potentiating factor (BPF7) separated from jellyfish, Cassiopia
andromeda, as a natural peptide on liver and kidney dysfunction resulting from indomethacin
in model ulcer animals. 60 male mice weighing (25-30 gm.) were used. They were divided
into six equal groups. The first group served as control. The second and third groups treated
orally with indomethacin (10mg/kg b.w) once day or day after the other respectively during
15 days. The fourth, fifth and sixth groups treated with BPF7 either alone or in combination
with indomethacin throughout the period of the experiment. Treatment with indomethacin
induced histological changes and several adverse effects on hepatic and renal tissues which
involve inflammation, cellular hypertrophy and glomerular shrinkage paralleled by a
significant increase in plasma ALT, AST, urea, uric acid and creatinine levels. These effects
were attributed to the hepatocellular and renal damage which in turn declined liver and
kidney functions. In contrast, BPF7 was a significantly ameliorates the deleterious effects
induced by indomethacin on these tested parameters without any histopathological changes in
hepatic or renal tissues. This improvement in studied parameters may be due to protein
biosynthesis and stimulation of glomerular filtration rate. Moreover, the activation of BK and
inhibition of angiotensin converting enzyme (ACE) by BPF7could produce protective effects
on renal and liver functions.