BACKGROUND: Acrylamide is reported for its toxicity on the central and the peripheral nervous system and causes paralysis. Bee venom (BV) and bradykinin-potentiating factor (BPF) have been documented for their potential therapeutic effects as anti-neuroinflammation. The study aimed to ameliorate the neurotoxic effects of acrylamide or chips by using BV or its extracted BPF. Mice were divided into 15 subgroups: ... Read more

BACKGROUND: Acrylamide has been reported to induce hepato- and nephrotoxicity. The present investigation aims to alleviate the dangerous effects at the histopathological and physiological levels of acrylamide by bee venom and its extracted bradykinin-potentiating factor (BPF). Seventy-five adult male mice were divided into 15 groups: a control (G1) 15 animals for 30 (G1.1), 45 (G 1.2), and 60 (G 1.3) ... Read more

ALPHA-SYNUCLEIN CONTRIBUTES TO NEURODEGENERATIVE DISEASES THAT ARE CHARACTERIZED WITH THE INCREASE OF ITS EXPRESSION AND COLLECTIVELY KNOWN AS SYNUCLEINOPATHIES SUCH AS PARKINSON’S DISEASE AND DEMENTIA WITH LEWY’S BODIES. A HEALTHY BALANCE OF ALPHA-SYNUCLEIN IS IMPORTANT FOR PREVENTING SYNUCLEINOPATHIES, WHEREAS THE NORMAL PHYSIOLOGICAL ROLE OF ALPHA-SYNUCLEIN IS STILL UNDER INVESTIGATION. THE PRESENT STUDY WAS DESIGNED TO EVALUATE THE INVOLVEMENT OF ALPHA-SYNUCLEIN ... Read more

Verapamil is a calcium channel blocker that belongs to the phenylalkylamine group. It has been clinically used for various diseases such as combating hypertension, ischemic heart diseases, supraventricular antiarrhythmic and tycolysis. The study was conducted to investigate the effect of verapamil on selected pro- and apoptotic factors during prenatal retinal differentiation of mice at E14 and E17 of gestation. The ... Read more

The present study was conducted to evaluate the effect of caffeine and retinoic acid as the active metabolite form of vitamin A on the liver at pre- and postnatal periods of development. In either the pre- or the postnatal period of study, caffeine was able to perturb carbohydrates, increase calcium and decrease iron those accompanied with down regulated expression of ... Read more

ABSTRACT The study was conducted to reveal the effect of retinoic acid (RA) on the developing embryonic organs in which the epithelia come to contact with mesenchyme in mice foetii during pregnancy at the onset of organogenesis. Histogenesis and the expression of TGFβ2 as a potent cell cytokine differentiator were evaluated in skin; lung, kidney and testis at 14, 18 ... Read more

Although, indomethacin is used in the treatment of some diseases, it is associated with side effects. Therefore, this study evaluates the effect of bradykinin potentiating factor (BPF7) as a natural products separated from the venom of jellyfish, Cassiopia andromeda on indomethacin-induced gastrointestinal ulceration and to examine the possibility of gastric ulcer healing by this natural peptides. The present study demonstrated ... Read more

Recently, the attention was focused on bioactive peptides obtained from natural sources and physiological significance of these substances in some diseases characterized by chronic inflammation and tissue damage. Therefore, this experiment was conducted to evaluate the role of bradykinin potentiating factor (BPF7) separated from jellyfish, Cassiopia andromeda, as a natural peptide on liver and kidney dysfunction resulting from indomethacin in ... Read more

This work was conducted to study the effect of uranium on TNFR2, TGFβ2 and (HSP70) as an active cell cytokines and induced protein for their important protective role. So, newly hatched larvae (one day old) of grass carp, _Ctenopharyngodonidella_, were exposed to ascending concentrations of uranium equivalent to 1, 2, 4, 8mg/l for a week of exposure. Deformations and percentages ... Read more

Abstract Lanthanum (LA) compounds are widely used in optics, electronics and therapeutics. The present study was undertaken to establish the experimental animal model the chick embryos for LA toxicity and its effect on pro-angiogenic growth factors (TGFβ2 and GDNF) as members of transforming growth factor superfamily. In fertilized eggs, LA was injected through the air chamber once time and the ... Read more