Several pathogenic bacteria are developing antibiotic resistance. Recovery from multidrug resistant (MDR) infections is a problematic issue and requires a multiple treatment with broad-spectrum antibiotics which are less effective, more toxic and more expensive. Silver nanoparticles (AgNPs) are attracting much interest because of their potent antibacterial and anti-biofilm activities. These nanoparticles are extensively synthesized and used as an effective broad spectrum antibacterial agent against Gram negative and Gram positive bacteria including antibiotic resistant bacteria. Silver attacks multiple targets in the microorganism therefore decreases its ability to develop resistance. Effect of coating on AgNPs stability, toxicity on the microbial host and their antimicrobial activity was discussed. The incorporation of AgNPs into hydrogels magnifies the