ZEN was evaluated in male adult mice; given single and repeated doses of ZEN (2.7 mg/kg B.W). Also
effect of Thymoquinone extracted from
Nigella Sativa was assessed. Mice were divided into 4 groups. G1: receiving
toxin once and dissected 48 h
rs later, G2: given toxin twice a week for one week, G3: given toxin twice a week for 2
weeks, G4: pretreated o rally by Thymoquinone (10 mg/Kg B.W) for 7 days prior to administration of ZEN twice a
week for two weeks. Blood serum urea nitrogen creatinine, alpha-fetoprotein, pyruvate kinase isoenzyme tumor M2
and total antioxidant status was assessed. All groups compared to control. The recovery occurred in TQ group based
on changes in level of all groups when comparing with G3. Histological changes of mice kidney coincided with
biochemical changes.
[Nagwa Mohammed EL-Sawi, Madeha Nooh Al-Seeni, Sabry H. H. Younes, Salma Mohammed AL-Jahdali, and
Soad Shaker Ali.
Biochemical and Histological Studies on the effect of Zearalenone Mycotoxin and
Thymoquinone on Male Mice Kidney.
J Am Sci 2012;8(10):378-388]. (ISSN: 1545-1003).