Patulin mycotoxin on some biochemical parameters and histological changes on male rats' liver and effect
of crude venom extracted from jelly fish Cassiopea Andromeda as a treatment. 50 Inbreeding weanling white male
wistar lewis rats were divided randomly into 5 groups. Control group was gavage fed daily with distilled water;
three treated groups were gavage fed daily dose with Patulin (0.2 mg/kg b.w.) for one, two and three weeks
respectively. The last group was treated by Patulin for one week then injected intraperitoneally with single dose of
crude venom (1.78 mg/20 g b.w.) for 24 hours according to LD
50. Level of (AST) and (GGT) were increased
significantly in serum of all treated groups compared with control group but level of (ALT) was increased
significantly in treated group after one week only. Although the concentration of (TNF-α) was increased
significantly and gradually in all treated groups, the concentration of ferritin was decreased significantly in treated
three after three weeks only. Histopathological changes of rat liver coincided with biochemical changes. In
conclusion, oral exposures of Patulin indicate that hepatic alteration was produced in manner related to dose
duration and crude venom may used as new therapeutic approach to detoxify hepatocytes from Patulin.
[Nagwa M. El-Sawi, Hanaa M. Gashlan, Sabry H. H. Younes, Rehab F. Al-Massabi and S. Shaker.
and histological studies on the effect of the Patulin mycotoxin on male rats’ liver and treatment by crude
venom extracted from jelly fish.
Life Sci J 2012;9(4):1143-1153]. (ISSN: 1097-8135)