Changes in cerebral perfusion are an important feature of the
pathophysiology of sickle cell anemia. This study was designed to
correlate between changes in cerebral perfusion and the impairment
in neurocognitive function in a group of sickle cell diseased children. A
total of 20 sickle cell diseased children from pediatric department of
Sohag University hospital were evaluated by transcrainal color and
duplex Doppler (TCD) via transtemporal approach. All patients
underwent MR imaging, and IQ tests.14 patients showed TCD finding
predictive of cerebrovascular disease ( TAMX> 170CM /sec).
They showed also impaired language development and reduction in I
Q. MRI finding suggestive of focal cerebral ischemic infarction were
found in only 2 of them. All the studied children had below average
social development. Our finding showed significant negative
correlation between TCD findings and neurocognitive functions in
children with sickle cell disease.