The fruit goji berry of Lyciumbarbarym, a traditional Chinese herbal medicine, has been widely used in healthy diets due to its potential role in the
prevention of chronic diseases. We studied the effects ofroridin A toxin in male
rat liver and their amelioration by goji extract. Thirtymale adult albino rats were
divided into three groups (10 rats each). Group 1 (Control group) was given only
the solvent(DMSO) of roridin A. Group 2 was administered a single dose (0.6 mg/
kg) of rordin A mycotoxin (dissolved in 1% DMSO) for one week. Group 3 was
treated prophylactically with goji extract (5 mg/kg) using gastric tube daily for 6
days and left for one week. Roridin A showed a highly signifcant increase in serum levels of cholesterol, triglycerides and signifcant increase inglucose, total antioxidants and tumor necrosis factor (TNF). There was signifcant decrease in serum ferritin level. On the other hand, administration of goji along with rordin A
showed a reduction in the above mentioned factors and elevation inferritin level.
Histopathological changes in the rat liver coincided with the above biochemical
changes. In conclusion; the treatment of rats with goji extract ameliorated the adverse effects of rordin A. Thus, gojimay be used asan antioxidant for certain toxins.
*Corresponding author: Elsawi, N. M. Department of Chemistry, Faculty of Science, Sohag University, Sohag, Egypt.
E-mail:
elsawinagwa@yahoo.com
Received Date: May 17, 2015
Accepted Date: July 28, 2015
Published Date: July 31, 2015