bstract: This study conducted a clinical trial to evaluate the relieving effects of Saussurea lappa on migraine patients. The results
showed that calcium and magnesium concentrations decreased significantly in patients while serotonin increased after two weeks of
treatment with Saussurea lappa. The drug (Amitriptyline 20mg/day and Ibuprofen 400mg/day) decreased alkaline phosphatase level
significantly, while Saussurea lappa had no effect on its level. This study found Saussurea lappa a safe and effective alternative
therapeutic agent which indicated that this root could have an effect in relieving headaches (migraine).
Key words: Migraine, saussurea lappa, serotonin, calcium and magnesium.