Total of 26 case were treated with voriconazole eye drops during the study period in addition voriconazole was used in the form of. Oral tablets ( n=16,61.5%) intracorneal injection (n=7,26.9%( and intracameral injection n=2,7.7% overall 50% n=13 of cases respond to medical treatment further definitive surgical intervation in the form of therapeutic keratoplasty was required in 11 case (42.3) . Two cases 7.7% under went enucelation For sever non resolving keratitis .non responders were more likely to have peripheral infilters 38.5% vs 7.7% p=0.16 and hypopyon 61.5% vs23%p=0.11 as compared with responders there was no significant variation in the microbiological results between responders and non responders