Moxifloxacin HCl is a fourth generation of fluoro-quinolone which has a broad spectrum and improved

anti-bacterial activity over other similar quinolones.Topical gel formulations of moxi.HCl were prepared by using gel forming agents like Carbopol 934, methyl cellulose, hydroxy propyl methylcellulose, sodium carboxy methyl cellulose and sodium alginate.Compatibility studies of the drug with these polymer were performed using DSC and FT-IR techniques.Physical characterization of Moxi.HCl gels including drug content , pH measurments and rheological parameter like viscosity were studied.In-vitro drug release from the prepared gel and kinetics of release were evaluated.Microbiological studies of moxi.HCl gels were carried out by using agar plate method aganist the tested micro-organisms.Wound healing study was performed on wound of mice infected with S.aeurus and P.aeuriginosa treated with the prepared gel .Results revealed that all the used polymers in gel preparations are compatible with moxi.HCl. All the prepared gels followed non-newtonian pseudo-plastic flow.Higher percent cumulative drug release was obtained from formula F3 containing 0.1%w⁄w moxi.HCl and using 6% w⁄v of sodium alginate as a gel base showed the lowest percent cumulative drug release after the same time .A slight decrease in the release rate of moxi.HCl was observed by increasing the concentration of the drug to 0.5%w⁄w in the prepared gels . The tesred formula ⟨F1- F5⟩ showed a higher antibacterial activity aganist S.aeurus and P.aeurginosa. Formula F3 showed a higher % of wound healing reached to 100% reduction in wound area after 6 days of topical treatments to mice with S.aeurus infected wound Hence from the ovelall study ,it was concluded that moxi.HCl gel would be promising in the treatment of wounds.