Moxifloxacin HCL (Moxi.HCL)  is a fourth generation fluoro- quinolone which has a broad spectrum anti-microbial effect on gram negative, gram positive micro-organisms and anaerobic bacteria.

Systemic Moxi. as oral tablets or parentral injections are used in treatment of different types of bacterial infections of lungs, stomach, pelvic , skin and skin structure infections (SSSIs). Systemic Moxi. has many side effects as nausea, diarrhea, headache, dizziness, rash, seizures and swelling or tearing of tendons.

The aim of this work was to prepare topical gel of Moxi. HCl to treat infected wounds and burns to avoid the sides effects of systemic preparations, decrease drug resistance and ensure tissue penetration . Topical gels of Moxi. HCl was prepared by using  carbopol934, cellulose derivatives e.g. (methyl cellulose, hydroxyl propyl methyl cellulose, sodium carboxy methyl cellulose) and sodium alginate. The use of gel as a delivery system can increase the residence time of drugs on  the skin, consequently, gels often provide a faster release of drug substance. Compatibility studies of  Moxi. HCL with the selected  polymers were performed using DSC and FT-IR. The prepared gel formulations  were evaluated  by studying the drug content, pH measurements, rheological properties and In-vitro drug diffusion. The diffusion results showed good diffusion of the drug from the gels prepared using methyl cellulose, hydroxyl propyl methyl cellulose and carbopol polymers. Microbiological studies  were performed on the prepared gels against  some micro-organisms which are considered the main causes of infection to burn and wound e.g. Staphylococcus aureus, E. coli, Methicillin–resistant Staphylococcus aureus (MERSA), Pseudomonas aeurginosa and klebsiella pneumonia. The results  showed efficient antimicrobial activity of the prepared gels.