eman_shalabi

Eman Muhammad Salah El-Deen Muhammad Shalabi

Professor - Professor Emeritus of Pathology

Faculty of medicine

Address: القوصية - محافظة أسيوط

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Diseases of Lymphoid and Hematopoietic Systems for Postgraduate Students of Pathology, Internal Medicine, Gasteroenterology & Tropical Medicine, General Surgery, and Oncology

2018-09-24 16:29:49 |

Diseases of Lymphoid System

Sites of Lymphoid Tissue

Primary lymphoid organs

Secondary lymphoid organs

Myeloid tissue

Lymphoid tissue

Normal anatomy of L.Ns

Inflammatory and hyperplastic diseases

Acute non specific lymphadenitis

Chronic non specific lymphadenitis

Reactive follicular hyperplasia

Paracortical hyperplasia

Sinus histiocytosis

Chronic specific lymphadenitis; Granulomatous lymphadenitis

Tuberculosis

Early tuberculous lymphadenitis

Caseating tuberculous lymphadenitis

Complications and effects

Sarcoidosis

Toxoplasmosis

Crohn’s disease

Cat scratch disease

Infectious mononucleosis

Tumors of lymphoid tissue

Primary tumors

Secondary tumors

Lymphoma

Hodgkin's Lymphoma

Incidence

Clinical picture

Gross picture

Reed-Sternberg cells (RSCs)

Atypical variants of RSCs

Classification of Hodgkin's Lymphoma

Microscopic subtypes

Nodular lymphocyte predominant HL

Lymphocytic predominant type

Nodular sclerosing type

Mixed cellularity type

Lymphocytic depletion type

Prognosis

Staging of Hodgkin's Lymphoma 

 

Non Hodgkin's Lymphoma

Special features of non Hodgkin’s lymphoma (NHL)

Comparison between  Hodgkin’s lymphoma and non Hodgkin’s lymphoma

Gross and Microscopic pictures

Immunohistochemistry

Classification (microscopic subtypes)

Rappaport Classification

Working Formulation

Kiel and Lukes and Collins classification

Real/WHO Classification (2001)

WHO classification of NHL

Precursor B and T Lymphocytes

B cell lymphoma

Follicular lymphoma

Diffuse small lymphocytic lymphoma

Diffuse lymphoplasmocytic lymphoma

Mantle cell lymphoma

Marginal zone lymphoma

Diffuse large B cell lymphoma (DLBCL)

Burkitt’s lymphoma

T cell lymphoma

Peripheral T cell lymphoma

Anaplastic large cell lymphoma (ALCL)

Mycosis fungoides

Clinical picture of NHL

Multiple Myeloma and related Plasma cell neoplasms

Plasma cell neoplasms

Multiple myeloma

Solitary plasmocytoma

Monoclonal gammopathy of undetrmind significance (MCGUS)

Causes of lymph node enlargement

Acute enlargement

Chronic L.N. enlargement

Diseases of the Spleen

Congenital anomalies

Hypersplenism

Primary hypersplenism

Secondary hypersplenism

Congestive Splenomegaly

Congestive Splenomegaly

Causes of enlargement of the spleen

Infectious causes

Congestive causes

Lymphohematogenous disorders

Immunologic inflammatory conditions

Miscellaneous

Diseases of Thymus

Hematological findings

Thymoma

Classifications

Diseases of the White Blood Cells

Variations in white blood cell counts

Leucocytosis

Causes of lymphocytosis

Eosinophilia

Monocytosis

Leucopenia

Agranulocytosis

Leukemia

Classifications

Acute leukemia

Myeloid (myeloblastic)

Monocytic (monoblastic)

Chronic leukemia

Myeloid (myelocystic)

Lymphatic (lymphocytic)

Chronic Leukemia

Chronic myeloid leukemia

Hematological finding

Total white cell count

Pathological findings

Spleen

Gross and Microscopic pictures

Liver

L.Ns

Other organs can also be affected

Anemia with fatty change

Thrombocytopenia leading hemorrhage

Chronic lymphocytic leukemia

Hematological finding

Pathological findings

L.Ns

Spleen

Liver

Skin and mucous membranes

Anemia

Comparison between chronic Myeloid Leukemia and chronic Lymphocytic Leukemia

Acute Leukemia

Hematological findings