Diseases of Lymphoid System
Sites of Lymphoid Tissue
Primary lymphoid organs
Secondary lymphoid organs
Myeloid tissue
Lymphoid tissue
Normal anatomy of L.Ns
Inflammatory and hyperplastic diseases
Acute non specific lymphadenitis
Chronic non specific lymphadenitis
Reactive follicular hyperplasia
Paracortical hyperplasia
Sinus histiocytosis
Chronic specific lymphadenitis; Granulomatous lymphadenitis
Tuberculosis
Early tuberculous lymphadenitis
Caseating tuberculous lymphadenitis
Complications and effects
Sarcoidosis
Toxoplasmosis
Crohn’s disease
Cat scratch disease
Infectious mononucleosis
Tumors of lymphoid tissue
Primary tumors
Secondary tumors
Lymphoma
Hodgkin's Lymphoma
Incidence
Clinical picture
Gross picture
Reed-Sternberg cells (RSCs)
Atypical variants of RSCs
Classification of Hodgkin's Lymphoma
Microscopic subtypes
Nodular lymphocyte predominant HL
Lymphocytic predominant type
Nodular sclerosing type
Mixed cellularity type
Lymphocytic depletion type
Prognosis
Staging of Hodgkin's Lymphoma
Non Hodgkin's Lymphoma
Special features of non Hodgkin’s lymphoma (NHL)
Comparison between Hodgkin’s lymphoma and non Hodgkin’s lymphoma
Gross and Microscopic pictures
Immunohistochemistry
Classification (microscopic subtypes)
Rappaport Classification
Working Formulation
Kiel and Lukes and Collins classification
Real/WHO Classification (2001)
WHO classification of NHL
Precursor B and T Lymphocytes
B cell lymphoma
Follicular lymphoma
Diffuse small lymphocytic lymphoma
Diffuse lymphoplasmocytic lymphoma
Mantle cell lymphoma
Marginal zone lymphoma
Diffuse large B cell lymphoma (DLBCL)
Burkitt’s lymphoma
T cell lymphoma
Peripheral T cell lymphoma
Anaplastic large cell lymphoma (ALCL)
Mycosis fungoides
Clinical picture of NHL
Multiple Myeloma and related Plasma cell neoplasms
Plasma cell neoplasms
Multiple myeloma
Solitary plasmocytoma
Monoclonal gammopathy of undetrmind significance (MCGUS)
Causes of lymph node enlargement
Acute enlargement
Chronic L.N. enlargement
Diseases of the Spleen
Congenital anomalies
Hypersplenism
Primary hypersplenism
Secondary hypersplenism
Congestive Splenomegaly
Congestive Splenomegaly
Causes of enlargement of the spleen
Infectious causes
Congestive causes
Lymphohematogenous disorders
Immunologic inflammatory conditions
Miscellaneous
Diseases of Thymus
Hematological findings
Thymoma
Classifications
Diseases of the White Blood Cells
Variations in white blood cell counts
Leucocytosis
Causes of lymphocytosis
Eosinophilia
Monocytosis
Leucopenia
Agranulocytosis
Leukemia
Classifications
Acute leukemia
Myeloid (myeloblastic)
Monocytic (monoblastic)
Chronic leukemia
Myeloid (myelocystic)
Lymphatic (lymphocytic)
Chronic Leukemia
Chronic myeloid leukemia
Hematological finding
Total white cell count
Pathological findings
Spleen
Gross and Microscopic pictures
Liver
L.Ns
Other organs can also be affected
Anemia with fatty change
Thrombocytopenia leading hemorrhage
Chronic lymphocytic leukemia
Hematological finding
Pathological findings
L.Ns
Spleen
Liver
Skin and mucous membranes
Anemia
Comparison between chronic Myeloid Leukemia and chronic Lymphocytic Leukemia
Acute Leukemia
Hematological findings
