Hematohidrosis is a mysterious and rare disorder characterized by one or more attacks of spontaneous, bloody sweating from intact surfaces of skin and/or mucous membranes. In the current literature, we faced a case of a 16-year old female who presented with recurrent attacks of right-sided bloody otorrhea upon exposure to extreme stress and anxiety. The patient had no history of ... Read more

Leukocytes that lack HLA allelic expression are frequently detected in patients with acquired aplastic anemia (AA) who respond to immunosuppressive therapy (IST), although the exact mechanisms underlying the HLA loss and HLA allele repertoire likely to acquire loss-of-function mutations are unknown. We identified a common nonsense mutation at position 19 (c. 19C> T, p. R7X) in exon 1 (Exon1 mut) ... Read more

The loss of killer cell Ig-like receptor ligands (KIR-Ls) due to the copy number–neutral loss of heterozygosity of chromosome 6p (6pLOH) in leukocytes of patients with acquired aplastic anemia (AA) may alter the susceptibility of the affected leukocytes to NK cell killing in vivo. We studied 408 AA patients, including 261 who were heterozygous for KIR-Ls, namely C1/C2 or Bw6/Bw4, ... Read more

Background: The S haemoglobin variant or sickle cell (SC) disorder is an inherited condition; a person may have sickle cell disease (SCD) or trait (SCT) if he/she inherited two copies of the mutated gene or single copy (heterozygous), respectively. SCT is commonly a neglected hematologic disorder with accidental discovery. Detection of SCT subjects is vital to prevent incidence of serious ... Read more

The plasticity of induced pluripotent stem cells (iPSCs) with the potential to differentiate into virtually any type of cells and the feasibility of generating hematopoietic stem progenitor cells (HSPCs) from patient-derived iPSCs (iPSC-HSPCs) has many potential applications in hematology. For example, iPSC-HSPCs are being used for leukemogenesis studies and their application in various cell replacement therapies is being evaluated. The ... Read more

Acquired aplastic anemia (AA) is a hematopoietic disorder caused by an immune attack on hematopoietic stem and progenitor cells (HSPCs) and has been thought to be rarely associated with the acquired genetic defects in HSPCs. However, recent studies have found that clonal hematopoiesis from HSPCs with genetic alterations is not so uncommon in AA Read more

Leukocytes that lack HLA class I alleles derived from hematopoietic stem and progenitor cells (HSPC) that undergo copy number-neutral loss of heterozygosity of the short arm of chromosome 6 (6pLOH) or HLA allelic mutations are often detected in patients with aplastic anemia (AA). The presence of HLA class I allele-lacking leukocytes provides compelling evidence that cytotoxic T-lymphocytes (CTL) are involved ... Read more

Hematopoietic stem cells (HSCs) that lack HLA-class I alleles as a result of copy-number neutral loss of heterozygosity of the short arm of chromosome 6 (6pLOH) or HLA allelic mutations often constitute hematopoiesis in patients with acquired aplastic anemia (AA), but the precise mechanisms underlying clonal hematopoiesis induced by these HLA-lacking (HLA2) HSCs remain unknown. To address this issue, we ... Read more

Leukocytes that lack HLA class I alleles derived from hematopoietic stem progenitor cells (HSPCs) that undergo copy number neutral loss of heterozygosity of the short arm of chromosome 6 (6pLOH) or HLA allelic mutations are often detected in acquired aplastic anemia (AA) patients. The presence of HLA class I allele-lacking leukocytes provides compelling evidence that CTLs are involved in the ... Read more

Acute myelogenous leukemia (AML) is a clinically heterogeneous disease that is frequently associated with relapse and a poor prognosis. Among the various subtypes, AML with the monosomal karyotype (AML-MK) has an extremely unfavorable prognosis. We performed screening to identify antitumorcompounds that are capable of inducing apoptosis in primary leukemia cellsharboring the AML-MK karyotype and identified a naturally occurring stilbene, Gnetin-C, ... Read more