Leukocytes that lack HLA class I alleles derived from hematopoietic stem and progenitor cells (HSPC) that undergo copy number-neutral loss of heterozygosity of the short arm of chromosome 6 (6pLOH) or HLA allelic mutations are often detected in patients with aplastic anemia (AA). The presence of HLA class I allele-lacking leukocytes provides compelling evidence that cytotoxic T-lymphocytes (CTL) are involved ... Read more

Acquired aplastic anemia (AA) is a hematopoietic disorder caused by an immune attack on hematopoietic stem and progenitor cells (HSPCs) and has been thought to be rarely associated with the acquired genetic defects in HSPCs. However, recent studies have found that clonal hematopoiesis from HSPCs with genetic alterations is not so uncommon in AA Read more

Leukocytes that lack HLA class I alleles derived from hematopoietic stem progenitor cells (HSPCs) that undergo copy number neutral loss of heterozygosity of the short arm of chromosome 6 (6pLOH) or HLA allelic mutations are often detected in acquired aplastic anemia (AA) patients. The presence of HLA class I allele-lacking leukocytes provides compelling evidence that CTLs are involved in the ... Read more