Clonal hematopoiesis by SLIT1 -mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia
Acquired aplastic anemia (AA) is a hematopoietic disorder caused by an immune attack on hematopoietic stem and progenitor cells (HSPCs) and has been thought to be rarely associated with the acquired genetic defects in HSPCs. However, recent studies have found that clonal hematopoiesis from HSPCs with genetic alterations is not so uncommon in AA Read more