Introduction: Leptin is a 167 - amino acid polypeptide hormone, identified in 1994 by positional cloning in the mouse and human. This hormone is secreted by the white adipose tissue in proportion to body energy (fat) stored. Leptin functions as a satiety factor in the regulation of body weight. So far, many studies have pointed to a direct role of ... Read more

Background: Cirrhosis often is a silent disease Clinical symptoms at presentation may include jaundice of the eyes or skin, pruritus, gastrointestinal bleeding, coagulopathy, increasing abdominal girth, and mental status changes. Pruritus may be the presenting symptom, arising years before any other classic clinical and laboratory markers of hepatic dysfunction. This study examines the clinical, laboratory and histopathological changes in the ... Read more

Vitiligo is an acquired autoimmune depigmentation of the skin, affecting 2%of the population with great impact on quality of life, which is more devastating in people with skin of color. The most important selection criterion in vitiligo for considering melanocyte keratinocyte transplantation procedure (MKTP) is stability. However, there is no consensus regarding the required period to define clinical stability. Moreover, ... Read more

BACKGROUND: Hepatic pruritus is a very common symptom among different chronic liver diseases, particularly in those related to cholestasis. Its prevalence is variable among liver diseases, ranging from 5% in chronic hepatitis C virus infection to 70% in primary biliary cirrhosis. Its etiopathogenesis remains poorly understood. Nerve growth factor (NGF) is a member of neurotrophins. many studies clearly demonstrate their ... Read more

Introduction: Microneedling is a relatively new minimally invasive procedure involving superficial and controlled puncturing of the skin by rolling with miniature fine needles. Traditionally used as a collagen induction therapy for skin rejuvenation and facial scars specially acne scars. Aim of the work: Evaluation of efficacy of microneedling in treatment of acne scars. Patients and Methods: Ten patients with post ... Read more

Male androgenetic alopecia (AGA) is the most common type of hair loss in men. It accounts for more than 90% of all cases of alopecia in men (1>. It occurs when genetically predisposed men are exposed to androgens. AGA may negatively affect patient's quality of life and can lead to social and job-related problems (21. AGA can also cause indirect ... Read more

Alopecia areata is a common cause of nonscarring alopecia that occurs in a patchy, confluent, or diffuse pattern. Dermoscopy is a noninvasive technique for the clinical diagnosis of many skin diseases. Topical minoxidil solution 5% and platelet rich plasma are important modalities used in treatment of alopecia areata. We aimed to evaluate the efficacy of PRP versus topical minoxidil 5% ... Read more

Background: Acne vulgaris is the most common dermatological condition encoun- tered in adolescents. Aim: It was to determine the prevalence of acne vulgaris and its impact of the quality of life among adolescents attending secondary schools in Sohag Province, Upper Egypt. Patients and methods: This was a cross-sectional study conducted in randomly selected governmental and technical secondary schools in Sohag ... Read more

* BACKGROUND: Chronic radio dermatitis is a frequent side effect of radiotherapy. It may be associated with decreased quality of life. AIMS: The aim of this study was to evaluate the clinical efficacy and safety of intralesional injection of triamcinolone acetonide for the treatment of patients with chronic radio dermatitis. METHODS: This study was a prospective clinical trial conducted on ... Read more

BACKGROUND: Skin diseases are a major health problem affecting a high proportion of the population and causing distress and disability. Disabled children may be particularly susceptible to skin disorders. Data regarding the dermatological problems encountered among physically and/or mentally challenged children are limited in Egypt. OBJECTIVES: The present study aimed to determine the pattern and the prevalence of skin diseases ... Read more