2(1-Acetyl-2-oxopropylidene)naphtho[2,3-d][1,3]dithiole-4,9-dione 1 reacts with a variety of bidentates reagents to give some new functionally substituted spiro naphthodithiole-4,9-dione derivatives. إقراء المزيد

Tramadol hydrochloride (T), (±)-cis-2-[(dimethylamino)- methyl]-1-(3-methoxyphenyl)cyclohexanol (1) [1-7] is a centrally acting analgesic agent used in the treatment of moderate to severe pain and as an alternative to opiates [8]. The sensitive analysis for drugs of abuse in seized materials or biological fluids has become important for forensic and toxicological laboratories. High performance liquid chromatography (HPLC) with ultraviolet (UV) [9-13] is ... إقراء المزيد

An efficient one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones or thiones is described using ceric ammonium nitrate (CAN) as a catalyst in the reaction of an aromatic aldehyde, β-ketoester and urea or thiourea under solvent free conditions in terms of excellent yields and very short reaction time. [Eman A. Ahmed, Mounir A. A. Mohamed and Ahmed M. M. El-Saghier. One-Pot Synthesis of Dihydropyrimidin-2(1H)-ones ... إقراء المزيد

In the title compound, C13H13N3O3, the pyrazolidine ring adopts a shallow envelope conformation, with the carbonyl C atom closest to the benzene ring as the flap [deviation of 0.126 (1) A ˚ from the plane through the remaining atoms (r.m.s. deviation = 0.011 A ˚ )]. The dihedral angle between the pyrazolidine ring (all atoms) and the benzene ring is ... إقراء المزيد

In the title compound, C15H17N3O2, the dihedral angle between the planes of the pyrazolidine and phenyl rings is 29.91 (6). The piperidine ring adopts a chair conformation. In the crystal, molecules are linked into chains running parallel to the a-axis direction by a combination of N—H O and C—H O hydrogen bonds. Furthermore, there exist C—H interactions and – stacking ... إقراء المزيد

Ceric Ammonium Nitrate (CAN), turns out to be commercially available, efficient and mild catalyst for synthesis of polyhydro-2Hcycloalka[ d]pyrimidinones and hexahydroquinazolinones in few minutes. Accompanied with Predictions of the activity spectra of some selected compounds using PASS INET. at Pa > 50%, showing high probability of Protein kinase (CK1) inhibitor and Alpha7 nicotinic receptor agonist. However Cycloheptene systems showed some ... إقراء المزيد

Condensation of 4-phenyl-1H-[1,5]benzodiazepin-2(3H)-one (1) with 3-formylchromone (2) afforded a mixture of 3-(chromenylmethylene)[1,5]benzodiazepinone 3 and 14-chromenylbenzodiazepino[ 2,3:6,5]pyrano[2,3-b]benzodiazepine 4. Ring rearrangements of compound 3 with different nucleophilic reagents, such as potassium hydroxide and/or ammonium acetate led to rearrangement into pyranobenzodiazepine 5 and pyridobenzodiazepine 6, respectively. Treatment of compound 3 with hydrazine hydrate, hydroxylamine hydrochloride, malononitrile, cyanothioacetamide, 2-cyano-3,3-disufanylacrylonitrile, and/or 2-cyano-3-phenylamino-3-sufanylacrylonitrile, has been carried ... إقراء المزيد

Nucleophilic substitution of 3-bromo-4-phenyl-1H-[1,5]benzodiazepin-2-one (1) with thiourea or guanidine in presence of potassium carbonate afforded 1,5-benzodiazepin-3-ylimidothiocarbamate 2 or 1,5- benzodiazepin-3-ylguanidine 3, respectively. Pyrimidylthiobenzodiazepines 5–13 were obtained via the reaction of compound 2 with malononitrile dimer, diethyl malonate, methylenemalononitriles, or a mixture of an aldehyde and β-keto esters or acetylacetone, catalyzed using ceric ammonium nitrate. Reaction of compound 2 or 3 ... إقراء المزيد

Reaction of (Z)-4-((dimethylamino)methylene)-1-phenylpyrazolidine- 3,5-dione (1) with different nucleophiles is described. Treatment of enaminone 1 with phenylhydrazine led to 3-oxo-N’,2-diphenyl- 2,3-dihydro-1H-pyrazole-4-carbohydrazide 7. New enaminone derivatives 2–6 and 12–14 were conveniently obtained in high yields via nucleophilic substitution of the dimethylamino group in enaminone 1 when reacted with o-aminophenol, o-aminothiophenol, ethanolamine, cysteamine hydrochloride, piperidine, morpholine, 2-aminopyridine and glycine. Reaction of enaminone 1 ... إقراء المزيد

The title compound, C15H12N4O2, contains two independent molecules in the asymmetric unit. These differ in terms of dihedral angles that the phenyl and 2-pyridyl rings subtend with the central five-membered ring; 15.2 (2) and 2.9 (2), respectively, in one molecule, 8.9 (2) and 5.1 (2)for the second. In the crystal, the independent molecules each self-associate to form layers through N—H ... إقراء المزيد