Torsemide (1-(1-Methylethyl)-3-[[4-[(3 methyl phenyl) amino] pyridin-3-yl] sulphonyl] urea) is an insoluble loop diuretic drug. Torsemide (TSM) is used for the treatment of oedema associated with heart failure, including pulmonary oedema, and with renal and hepatic disorders. It is also used in the treatment of hypertension, either alone or in combination with other antihypertensive drugs. Complexation of the drug with beta ... Read more

ABSTRACT The main objective of this study is the preparation of different topical formulations of controlled release niosomal gel containing Ketorolac tromethamine (KT) niosomes to avert problems associated with KT such as gastrointestinal irritation and short half-life. Niosomes as a colloidal carrier of KT were prepared by ether injection method then incorporated into different gel bases as sodium alginate (Na ... Read more

Niosomes have been reported to deliver the drug at a lower concentration over prolonged period of time to the target site and so reducing the potential dose related side effects. The purpose of the present study was to prepare, characterize and optimize Ketorolac Tromethamine (KT) niosomes for topical applications. This could be achieved by using ether injection method for preparing ... Read more

Abstract: This study was designed to evaluate the suitability of Pluronic F-127, different grades of Carbopol and cellulosic polymers as gel bases containing tolmetin, a nonsteroidal anti-inflammatory drug. In vitro release characteristics, effect of enhancers, viscosity and the mechanism of drug release for different gel bases was studied as well as the anti-inflammatory activity were evaluated. The results showed that ... Read more

ABSTRACT: The objective of this work was to use a full factorial design and response surface methodology to optimize and prepare fast disintegrating tablets of Itopride hydrochloride (ITOHCl). Tablets were prepared by direct compression technique and evaluated for their drug content, weight variation, hardness, friability, wetting, disintegration time, and _in-vitro_ release. In addition, the optimum formulation was evaluated for taste, ... Read more

Eudragit RL100 films containing piroxicam 4 % (w/w of polymer) were prepared and investigated as potential drug delivery systems for the controlled release purpose. Effect of different plasticizers such as glyceryltributyrate (GTB), glyceryl triacetate (GTA), propylene glycol (PG) and polyethylene glycol 400 (PEG 400) on the drug release from the medicated films was studied. Moreover, effect of different drug release ... Read more

Abstract Emulsification/internal gelation has been suggested as an alternative to extrusion/external gelation in the encapsulation of several compounds including non-steroidal anti-inflammatory drugs such as diclofenac sodium. The objective of the present study was a trial to formulate diclofenac sodium as controlled release microparticles that might be administered once or twice daily. This could be achieved via emulsification/internal gelation technique applying ... Read more

Zagazig Journal of Pharmaceutical Sciences (ZJPS) is a peer-reviewed Scientific Journal published by Faculty of Pharmacy, Zagazig University. The Journal is devoted to the advancement and dissemination of scientific knowledge concerning different disciplines of Pharmaceutical Sciences and related subjects. Read more

_In a trial to delay the release rate of diclofenac sodium from alginate coated microcapsules, the use of a copolymer was suggested. Mixtures of polymers can have a significant properties than that of individual polymer to achieve sustained release microcapsules. On considering the negative charge of alginate and its ability to form polyionic complexes with a lowered tendency of erosion ... Read more

The purpose of this study was to prepare and characterize controlled release ketorolac tromethamine microspheres. To achieve this goal, cellulose acetate butyrate microspheres loaded by ketorolac tromethamine were prepared by the emulsion solvent evaporation method. The prepared ketorolac tromethamine microspheres were evaluated for their production yields, particle size distribution, morphology, drug content and drug release characteristics. Thermal Gravimetric Analysis (TGA) ... Read more