Mahmoudalmenshawy

Mahmoud Mohamed Ahmed Elsayed

Professor - Former Dean of Faculty of Pharmacy- Sohag University

Faculty of Pharmacy

Address: Faculty of Pharmacy, Pharmaceutics and Clinical Pharmacy Department,Sohag University, Sohag, Egypt

24

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Tailoring of Novel Azithromycin-Loaded Zinc Oxide Nanoparticles for Wound Healing
Skin is the largest mechanical barrier against invading pathogens. Following skin injury, the healing process immediately starts to regenerate the damaged tissues and to avoid complications that usually include colonization by pathogenic bacteria, leading to fever and sepsis, which further impairs and complicates the healing process. So, there is an urgent need to develop a novel pharmaceutical material that promotes ... Read more

Novel Green Biosynthesis of 5-Fluorouracil Chromium Nanoparticles Using Harpullia pendula Extract for Treatment of Colorectal Cancer
Colorectal cancer (CRC) is the third highest major cause of morbidity and mortality worldwide. Hence, many strategies and approaches have been widely developed for cancer treatment. This work prepared and evaluated the antitumor activity of 5-Fluorouracil (5-Fu) loaded chromium nanoparticles (5-FuCrNPs). The green biosynthesis approach using Harpullia (H) pendula aqueous extract was used for CrNPs preparation, which was further loaded ... Read more

Design and Optimization of Orally Administered Luteolin Nanoethosomes to Enhance Its Anti-Tumor Activity against Hepatocellular Carcinoma
Luteolin (LUT) is a natural flavonoid with low oral bioavailability with restricted clinical applications due to its low solubility. LUT shows significant anti-tumor activity in many cancer cells, including hepatocellular carcinoma (HCC). The most recent trend in pharmaceutical innovations is the application of phospholipid vesicles to improve the solubility of such hydrophobic drugs. Ethosomes are one of the most powerful ... Read more

2020 | Keywords
Controlled Release Alginate- Chitosan Microspheres of Tolmetin Sodium Prepared by Internal Gelation Technique and Characterized by Response Surface Modeling
Tolmetin sodium (TS) is a powerful non-steroidal mitigating drug for the treatment of rheumatoid joint inflammation, osteoarthritis, and adolescent rheumatoid joint pain. In addition to its gastrointestinal (GIT) problems, TS has a short biological half-life (1 hr). In a trial to overcome these side effects and control the rate of (TS) release, chitosan coated alginate microspheres are recommended. A Box-Behnken ... Read more

2019 | Keywords sorafenib, carbon nanotubes,
Accelerated Stability Testing of Microcapsulated Sorafenib-loaded Carbon nanotubes Prepared by emulsification/internal gelation Method
This work aims to evaluate the effect of environmental factors, including temperature, humidity, and light, on the quality of a drug substance or a formulated product which is utilized for prediction of its shelf life, to determine proper storage conditions and to suggest labeling instructions. Moreover, the data generated during the stability testing is an important requirement for regulatory approval ... Read more

2019 | Keywords Microspheres, sorafenib,
EFFECT OF DIFFERENT FORMULATION VARIABLES ON RELEASE CHARACTERISTICS OF GASTRO-FLOATING MICROSPHERES OF ETHYL CELLULOSE/CARBOPOL 934P ENCAPSULATING SORAFENIB
Objective: The aim of this study is to prepare floating hollow microspheres encapsulating Sorafenib (SFN) to enhance its oral bioavailability. Methods: Gastro-floating hollow adhesive microspheres containing SFN were produced by using an emulsion solvent evaporation technique with ether and ethanol as solvents. Ethyl cellulose and carbopol 934P were used as the encapsulating carriers. The effects of formulation parameters like, solvent ... Read more

2019 | Keywords Propolis,
Modified Spraying Technique and Response Surface Methodology for the Preparation and Optimization of Propolis Liposomes of Enhanced Anti-Proliferative Activity against Human Melanoma Cell Line A375
Propolis is a honeybee product that contains a mixture of natural substances with a broad spectrum of biological activities. However, the clinical application of propolis is limited due to the presence of a myriad of constituents with dierent physicochemical properties, low bioavailability and lack of appropriate formulations. In this study, a modified injection technique (spraying technique) has been developed for ... Read more

2019 | Keywords sorafenib, Nanotechnology,
Design And Characterisation Of Novel Sorafenib-Loaded Carbon Nanotubes With Distinct Tumour-Suppressive Activity In Hepatocellular Carcinoma
Purpose: Over the past 30 years, no consistent survival benefits have been recorded for anticancer agents of advanced hepatocellular carcinoma (HCC), except for the multikinase inhibitor sorafenib (Nexavar®), which clinically achieves only ~3 months overall survival benefit. This modest benefit is attributed to limited aqueous solubility, slow dissolution rate and, consequently, limited absorption from the gastrointestinal tract. Thus, novel formulation ... Read more

2019 | Keywords Ketorolac Tromethamine,
Response Surface Methodology as a Useful Tool for Development and Optimization of Sustained Release Ketorolac Tromethamine Niosomal Organogels
Purpose Niosomes as vesicular frameworks are novel methods of delivering a drug in a sustained manner to enhance its bioavailability and get therapeutic effect over a longer period time. This study conclusively demonstrates the preparation, characterization, and optimization of sustained release ketorolac tromethamine (KT) niosomal organogels to enhance skin permeation and increase drug efficacy. Methods The ether injection method was ... Read more

2019 | Keywords Propolis,
Modified Spraying Technique and  Response Surface Methodology for the Preparation and Optimization of Propolis Liposomes of Enhanced Anti-Proliferative Activity against Human Melanoma Cell Line A375
Propolis is a honeybee product that contains a mixture of natural substances with a broad spectrum of biological activities. However, the clinical application of propolis is limited due to the presence of a myriad of constituents with different physicochemical properties, low bioavailability and lack of appropriate formulations. In this study, a modified injection technique (spraying technique) has been developed for ... Read more