Mahmoudalmenshawy

Mahmoud Mohamed Ahmed Elsayed

Professor - Former Dean of Faculty of Pharmacy- Sohag University

Faculty of Pharmacy

Address: Faculty of Pharmacy, Pharmaceutics and Clinical Pharmacy Department,Sohag University, Sohag, Egypt

22

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2020 | Keywords
Controlled Release Alginate- Chitosan Microspheres of Tolmetin Sodium Prepared by Internal Gelation Technique and Characterized by Response Surface Modeling
Tolmetin sodium (TS) is a powerful non-steroidal mitigating drug for the treatment of rheumatoid joint inflammation, osteoarthritis, and adolescent rheumatoid joint pain. In addition to its gastrointestinal (GIT) problems, TS has a short biological half-life (1 hr). In a trial to overcome these side effects and control the rate of (TS) release, chitosan coated alginate microspheres are recommended. A Box-Behnken ... Read more

2019 | Keywords sorafenib, carbon nanotubes,
Accelerated Stability Testing of Microcapsulated Sorafenib-loaded Carbon nanotubes Prepared by emulsification/internal gelation Method
This work aims to evaluate the effect of environmental factors, including temperature, humidity, and light, on the quality of a drug substance or a formulated product which is utilized for prediction of its shelf life, to determine proper storage conditions and to suggest labeling instructions. Moreover, the data generated during the stability testing is an important requirement for regulatory approval ... Read more

2019 | Keywords Microspheres, sorafenib,
EFFECT OF DIFFERENT FORMULATION VARIABLES ON RELEASE CHARACTERISTICS OF GASTRO-FLOATING MICROSPHERES OF ETHYL CELLULOSE/CARBOPOL 934P ENCAPSULATING SORAFENIB
Objective: The aim of this study is to prepare floating hollow microspheres encapsulating Sorafenib (SFN) to enhance its oral bioavailability. Methods: Gastro-floating hollow adhesive microspheres containing SFN were produced by using an emulsion solvent evaporation technique with ether and ethanol as solvents. Ethyl cellulose and carbopol 934P were used as the encapsulating carriers. The effects of formulation parameters like, solvent ... Read more

2019 | Keywords Propolis,
Modified Spraying Technique and Response Surface Methodology for the Preparation and Optimization of Propolis Liposomes of Enhanced Anti-Proliferative Activity against Human Melanoma Cell Line A375
Propolis is a honeybee product that contains a mixture of natural substances with a broad spectrum of biological activities. However, the clinical application of propolis is limited due to the presence of a myriad of constituents with dierent physicochemical properties, low bioavailability and lack of appropriate formulations. In this study, a modified injection technique (spraying technique) has been developed for ... Read more

2019 | Keywords sorafenib, Nanotechnology,
Design And Characterisation Of Novel Sorafenib-Loaded Carbon Nanotubes With Distinct Tumour-Suppressive Activity In Hepatocellular Carcinoma
Purpose: Over the past 30 years, no consistent survival benefits have been recorded for anticancer agents of advanced hepatocellular carcinoma (HCC), except for the multikinase inhibitor sorafenib (Nexavar®), which clinically achieves only ~3 months overall survival benefit. This modest benefit is attributed to limited aqueous solubility, slow dissolution rate and, consequently, limited absorption from the gastrointestinal tract. Thus, novel formulation ... Read more

2019 | Keywords Ketorolac Tromethamine,
Response Surface Methodology as a Useful Tool for Development and Optimization of Sustained Release Ketorolac Tromethamine Niosomal Organogels
Purpose Niosomes as vesicular frameworks are novel methods of delivering a drug in a sustained manner to enhance its bioavailability and get therapeutic effect over a longer period time. This study conclusively demonstrates the preparation, characterization, and optimization of sustained release ketorolac tromethamine (KT) niosomal organogels to enhance skin permeation and increase drug efficacy. Methods The ether injection method was ... Read more

2019 | Keywords Propolis,
Modified Spraying Technique and  Response Surface Methodology for the Preparation and Optimization of Propolis Liposomes of Enhanced Anti-Proliferative Activity against Human Melanoma Cell Line A375
Propolis is a honeybee product that contains a mixture of natural substances with a broad spectrum of biological activities. However, the clinical application of propolis is limited due to the presence of a myriad of constituents with different physicochemical properties, low bioavailability and lack of appropriate formulations. In this study, a modified injection technique (spraying technique) has been developed for ... Read more

2017 | Keywords Fast Dissolving tab, Torsemide,
Torsemide Fast Dissolving Tablets: Development, Optimization Using Box-Bhenken Design and Response Surface Methodology, In Vitro Characterization, and Pharmacokinetic Assessment.
ABSTRACT The present study planed to develop new fast dissolving tablets (FDTs) of torsemide. Solid dispersions (SDs) of torsemide and sorbitol (3:1) or polyvinylpyrrolidone (PVP) k25 were prepared. The prepared SDs were evaluated for in-vitro dissolution. Fourier transform infrared spectroscopy and differential scanning calorimetry for SDs revealed no drug/excipient interactions and transformation of torsemide to the amorphous form. Torsemide/sorbitol SD ... Read more

2016 | Keywords niosomal gel,
Controlled Release Niosomal Gel as a Colloidal Carrier for Topical Drug Delivery of Ketorolac Tromethamine
ABSTRACT The main objective of this study is the preparation of different topical formulations of controlled release niosomal gel containing Ketorolac tromethamine (KT) niosomes to avert problems associated with KT such as gastrointestinal irritation and short half-life. Niosomes as a colloidal carrier of KT were prepared by ether injection method then incorporated into different gel bases as sodium alginate (Na ... Read more

2016 | Keywords Torsemide,
Enhancement of Solubility and Dissolution Rate of Torsemide as Poorly Soluble Loop Diuretic by Inclusion Complexation with both β -Cyclodextrin and Hydroxypropyl-β -Cyclodextrin
Torsemide (1-(1-Methylethyl)-3-[[4-[(3 methyl phenyl) amino] pyridin-3-yl] sulphonyl] urea) is an insoluble loop diuretic drug. Torsemide (TSM) is used for the treatment of oedema associated with heart failure, including pulmonary oedema, and with renal and hepatic disorders. It is also used in the treatment of hypertension, either alone or in combination with other antihypertensive drugs. Complexation of the drug with beta ... Read more