Breast cancer has emerged as a grave danger in the last 50 years. It represented 35.1% of total cancer in women in Egypt National Cancer Institute (NCI) series. Changes in cell loss factor could have a major impact on tumor growth or regression. A large percentage of cell loss from tumors was due to apoptosis. P53 is a tumor suppressor ... إقراء المزيد

BACKGROUND/AIMS: Breast cancer is the most common cancer in Egyptian women. This study aims to: 1. Evaluate COX-2 and p53 expressions in the successive steps of breast carcinogenesis. 2. Determine the correlation between COX-2 and p53 with the clinico-pathological parameters in ductal breast carcinoma. PATIENTS AND METHODS: This study included 74 specimens of breast lesions. Data about patient’s age, tumor ... إقراء المزيد

BACKGROUND: Breast cancer is the most common cancer in Egyptian women. COX-2 seems to be involved in malignant transformation and tumor progression by affecting cell proliferation, mitosis, cell adhesion, apoptosis, immune surveillance, and angiogenesis. Angiogenesis is an important key step in tumor progression. Microvascular density (MVD), a surrogate marker of angiogenesis can be assessed by CD31 staining. AIMS This study ... إقراء المزيد

BACKGROUND: Breast cancer represents a group of tumors with a tremendous heterogeneity in its behavior, outcome, and response to therapy. Angiogenesis is an important key step in tumor progression. Microvascular density (MVD), a surrogate marker of angiogenesis can be assessed by CD31 immunostaining. THIS STUDY AIMS TO evaluate CD31 and p53 expressions in breast cancer, and to determine their correlations ... إقراء المزيد