Introduction • Infectious bronchitis virus (IBV) is a coronavirus, that initially replicate in respiratory tract of chickens and ultimately reach reproductive, renal and lymphoid organs to establish a systemic infection. • The virus has the potential to persist in the cecal tonsils and maintain the viral shedding even when the respiratory tract has cleared the infection. The microbiome plays a ... Read more

The Spike (S) gene encodes the S envelope glycoprotein and encoded by the amino-terminus S1 gene, and the carboxyl-terminus S2 gene (de Haan et al., 2004). The S1 gene contains 3 hypervariable regions (HVR) crucial for viral infectivity, with high rates of substitution and recombination due to the RNA nature of the virus (Moreno et al., 2017). The “quasispecies” concept, ... Read more

IBV, avian corona virus causes significant economic burdens on the Canadian poultry industry, with annual losses about $207 million due to decreased production IBV, 40 % lowered egg production in clinically healthy laying hens following 1 d-old chick experimental infection with Canadian DMV/1639 strain [Dr. Careem group, Viruses, 2021]. Read more

Infectious Bronchitis Virus (IBV) infection poses significant challenges to poultry health and production. This study investigates the modulation of inflammatory cell death pathways in IBV-infected macrophages through inhibiting either caspases or COX-2/PGE2 pathway. We measured intracellular and extracellular viral genome loads, cell viability, apoptosis, and necroptosis after infecting cells with two disparate IBV strains, respiratory Conn A5968 and nephropathogenic DMV/1639. ... Read more

Infectious bronchitis virus (IBV) induces severe economic losses in chicken farms due to the emergence of new variants leading to vaccine breaks. The studied IBV strains belong to Massachusetts (Mass), Canadian 4/91, and California (Cal) 1737 genotypes that are prevalent globally. This study was designed to compare the impact of these three IBV genotypes on primary and secondary lymphoid organs. ... Read more

this study, we investigated the localized pathogenesis of infectious bronchitis virus (IBV) in chicken tracheal organ cultures (TOCs), focusing on the role of inducible cyclooxygenase (COX-2). Two divergent IBV strains, respiratory Connecticut (Conn) A5968 and nephropathogenic Delmarva (DMV)/1639, were studied at 6, 12, 24, and 48 hours post-infection (hpi). Various treatments including exogenous prostaglandin (PGE)2, a selective COX-2 antagonist (SC-236), ... Read more