Differential impact of Massachusetts, Canadian 4/91 and California (Cal) 1737 genotypes of infectious bronchitis virus infection on lymphoid organs of chickens.

2024-10-26 12:29:52 | Keywords IBV, Lymphoid organs, chicken, |

Journal name	Viruses
Publication year	2024
Auther	Abd-Elsalam R M., Najimudeen SM, ME. Mahmoud et al.,
Publication DOI or URL	https://doi.org/10.3390/v16030326

Infectious bronchitis virus (IBV) induces severe economic losses in chicken farms due

to the emergence of new variants leading to vaccine breaks. The studied IBV strains belong to

Massachusetts (Mass), Canadian 4/91, and California (Cal) 1737 genotypes that are prevalent globally.

This study was designed to compare the impact of these three IBV genotypes on primary and

secondary lymphoid organs. For this purpose, one-week-old specific pathogen-free chickens were

inoculated with Mass, Canadian 4/91, or Cal 1737 IBV variants, keeping a mock-infected control.

We examined the IBV replication in primary and secondary lymphoid organs. The molecular,

histopathological, and immunohistochemical examinations revealed significant differences in lesion

scores and viral distribution in these immune organs. In addition, we observed B-cell depletion in

the bursa of Fabricius and the spleen with a significant elevation of T cells in these organs. Further

studies are required to determine the functional consequences of IBV replication in lymphoid organs.

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