Melatonin attenuates chronic immobilization stress-induced muscle atrophy in rats: Influence on lactate-to-pyruvate ratios and Na+/K+ ATPase activit
This study assessed the protective effect of melatonin against muscle atrophy provoked by chronic immobi ization stress (CIS). CIS was induced in rats by limiting their trunk movement for 90min daily for 6 weeks. Rats subjected to the CIS procedure demonstrated a substantial decrease in body weight, an increase in serum corticosterone, muscle atrophy, and an increase in atrogin-1 mRNA ... Read more