ABSTRACT BACKGROUND: post menopausal period is a critical period for each female. How to minimize the complications of this period is a matter of major concern. MATERIALS AND METHODS: 40 females' albino rates were included in this study; they were divided into four equal groups. G1: Sham ovariectomized group, G2: ovariectomized group receiving vehicle (Ve) 1mg/kg/day for 7 weeks intraperitoneal ... Read more

This study assessed the protective effect of melatonin against muscle atrophy provoked by chronic immobi ization stress (CIS). CIS was induced in rats by limiting their trunk movement for 90min daily for 6 weeks. Rats subjected to the CIS procedure demonstrated a substantial decrease in body weight, an increase in serum corticosterone, muscle atrophy, and an increase in atrogin-1 mRNA ... Read more

MANY APOPTOTIC MARKERS HAVE BEEN LINKED TO HEPATIC CELL INJURY IN HCV-RELATED LIVER DISEASES, AND HENCE COULD BE USED AS POTENTIAL MARKERS FOR EARLY DETECTION OF THE DISEASE. THE PRESENT STUDY AIMED TO ASSESS THE ROLE OF APOPTOTIC MARKERS BCL-2 AND BAX IN THE PATHOGENESIS OF CHRONIC HCV-RELATED LIVER DISEASES. A TOTAL OF 85 PARTICIPANTS WERE ENROLLED INTO THE STUDY; ... Read more

ABSTRACT Background: Skeletal muscle fatigue due to unaccustomed hard and/or prolonged physical exercise may be caused by increase of lactic acid, inflammatory mediators and oxidative stress. Stimulation of H1 receptors by histamine and the ensuing production of nitric oxide trigger the vasodilating effect of histamine on arterioles in exercise to supply O2 and nutrients and removal of CO2 and waste ... Read more

Dexmedetomidine (Dex) is a novel Alpha 2-adrenoceptor agonist. It decreases sympathetic tone and attenuates the stress responses to anesthesia and surgery. People exposed to cold suffer unpleasant thermal pain, which is experienced as stress and causes the release of noradrenaline from the sympathetic terminals. The present study investigated the effects of cold stress and dexmedetomidine on chronic constriction injury (CCI) ... Read more