Acute lymphoblastic leukemia (ALL) is a clonal malignant disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow (JIANG ET AL., 2010). Cytogenetic abnormalities are independent prognostic variables for predicting the outcome of adult ALL patients. Recent genomic studies have provided a refined genetic map of acute lymphoblastic leukemia (ALL) ... Read more

ABSTRACT BACKGROUND. Acute lymphoblastic leukemia (ALL) is a malignant disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. Philadelphia chromosome (Ph)-positive ALL, a high-risk cytogenetic subset, accounts for 25-30% of adult ALL cases but occurs in less than 5% of children. We aimed with this study to detect Ph ... Read more