Background: Pruritus is a distressing symptom of cholestatic, inflammatory,and malignant liver diseases. It is a common symptom in many biliary andcholestatic disorders such as primary biliary cirrhosis (PBC). Several mechanisms are generally accepted as possible explanations to the underlying basis of itch.However, the exact pathophysiology of pruritus in liver diseases remains unclear.The cutaneous and central neurobiology of pruritus is complex ... إقراء المزيد

Background: Pruritus is a distressing symptom of cholestatic, inflammatory, and malignant liver diseases. It is a common symptom in many biliary and cholestatic disorders such as primary biliary cirrhosis (PBC). Several mechanisms are generally accepted as possible explanations to the underlying basis of itch. However, the exact pathophysiology of pruritus in liver diseases remains unclear. The cutaneous and central neurobiology ... إقراء المزيد

Background: Nerve growth factor (NGF) and its high-affinity recep- tor, tyrosine kinase A (TrkA), are members of the neurotrophin family. NGF–TrkA are involved in murine hair morphogenesis and cycling. To date, their expression in human hair follicle (HF) is unknown. In this investigation, we hypothesize that NGF–TrkA proteins are expressed in the human scalp skin. Moreover, NGF–TrkA expression in HF ... إقراء المزيد