Sexuality is one of the most important components of quality of life in both sexes. Female Sexual Dysfunction are a complex, poorly understood and underestimated health problem although it is a highly prevalent include disorders of desire, arousal, orgasm and sexual pain associated with self-distress. Pathophysiology of FSD has been related to several factors. In response to an overwhelming demand for therapy for FSD several drugs are undergoing development and testing, such as hormonal replacement therapy, PDE5, prostaglandin E1 and flibanserin beside psychotherapy.
Aim of the work: Evaluate the effect of sildenafil citrate in treatment of female sexual dysfunction.
Patient, Materials and Methods: An observational study had been done on 43 females complaining of FSD who were fulfilling the inclusion criteria. They were taken oral sildenafil citrate 25mg daily for 6 weeks and were evaluated by 19–items Female Sexual Function Index (FSFI) questionnaire before and after treatment.
Results: Our results showed that 34.4% became normal with score >26.5; while 65.6% showed some improvement but still have FSD (FSFI<26.5). There was significant improvement in all female sexual domains in FSFI ranged from 21% to 69%. There was significant improvement of total score in both 1st degree circumcision more than 2nd degree circumcisions with 41%- 35% respectively.
Conclusion: We concluded that the treatment of patients with FSD by sildenafil citrate 25mg daily for 6 weeks had significant improvement effect on all subtypes of FSD according to FSFI questionnaire.