Journal name |
Royal society Open Science |
Publication year |
2020 |
Auther |
3. Mohamed A. Abdel-Lateef, Sayed M Derayea, Deena A. M. Nour El-Deen, Mohamed Oraby |
Publication DOI or URL |
https://doi.org/10.1098/rsos.201545 |
Terbinafine hydrochloride is a potent antifungal drug indicated
for oral and topical treatment of mycoses. A resonance Rayleigh
scattering (RRS) method was developed for the determination
of terbinafine hydrochloride through a feasible complexation
reaction with erythrosine B. In a weakly acidic medium (acetate
buffer, pH 5.0), terbinafine hydrochloride can react with
erythrosine B through the electrostatic attraction and virtue of
hydrophobic force to form an ion-association complex. The
reaction resulted in the appearance of a new RRS peak at
369 nm. The RRS peak was increased by increasing the
concentration of terbinafine hydrochloride in the linear range of
0.1–1.5 µg ml−1
. All the reaction conditions (erythrosine B
concentration, buffer volume, diluting solvent and pH) were
optimized. The detection limit was 0.029 µg ml−1 while the
quantitation limit was 0.089 µg ml−1
. The suggested method
after its validation was successfully applied for the
determination of terbinafine hydrochloride in different
pharmaceutical formulations (tablets and cream) with sufficient
recovery.