|Biosensors and Bioelectronics
|K. Yugender Goud, K. Koteshwara Reddy , Ahmed Khorshed , V. Sunil Kumar , Rupesh K. Mishra , Mohamed Oraby , Alyaa Hatem Ibrahim, Hern Kim b, K. Vengatajalabathy Gobi
|Publication DOI or URL
Infectious diseases caused by viruses can elevate up to undesired pandemic conditions affecting the global
population and normal life function. These in turn impact the established world economy, create jobless situations, physical, mental, emotional stress, and challenge the human survival. Therefore, timely detection, treatment, isolation and prevention of spreading the pandemic infectious diseases not beyond the originated town is
critical to avoid global impairment of life (e.g., Corona virus disease - 2019, COVID-19). The objective of this
review article is to emphasize the recent advancements in the electrochemical diagnostics of twelve lifethreatening viruses namely - COVID-19, Middle east respiratory syndrome (MERS), Severe acute respiratory
syndrome (SARS), Influenza, Hepatitis, Human immunodeficiency virus (HIV), Human papilloma virus (HPV),
Zika virus, Herpes simplex virus, Chikungunya, Dengue, and Rotavirus. This review describes the design, principle, underlying rationale, receptor, and mechanistic aspects of sensor systems reported for such viruses.
Electrochemical sensor systems which comprised either antibody or aptamers or direct/mediated electron
transfer in the recognition matrix were explicitly segregated into separate sub-sections for critical comparison.
This review emphasizes the current challenges involved in translating laboratory research to real-world device
applications, future prospects and commercialization aspects of electrochemical diagnostic devices for virus
detection. The background and overall progress provided in this review are expected to be insightful to the
researchers in sensor field and facilitate the design and fabrication of electrochemical sensors for life-threatening
viruses with broader applicability to any desired pathogens.