Vitiligoisadisfiguringdiseaseaffectingskinandmucousmembranes
causingsocialstigma.CharacterisedbyMilkyWhitepatches,duetoloss
ofmelanocytes.Itremainsunclearwhatcausesdamageordeathtothe
melanocytes,therearemanypotentialpathophysiologicaltheories
involvingautoimmune,neural,autocytotoxic,biochemical,oxidative
stress,melanocytorrhagy,anddecreasedmelanocytesurvival
hypotheses.
Theexactmechanism ofactionofPRPinvitiligoisstillunknown.The
beneficialeffectofPRPinvitiligocouldbesuggestedthroughthese
growthfactorswhichstimulatekeratinocytesandfibroblastsproliferation
withsubsequentimprovementoftheirinteractionwithmelanocytes
leadingtothestabilizationofmelanocytes.
2
Conclusion
Vitiligoisacommondistressingdiseasewithsocialandpsychological
effects,newmodalitiesoftreatmenthavebeenintroducedwithpromising
effectofPRP,combinedwithothertreatments