Toxoplasmosis is a protozoan infection caused by Toxoplasma gondii. We report a case of Toxoplasma gondii and Clostridium
perfringens co-infection complicating uterine gas gangrene following a term pregnancy. The histologic examination of the
uterine necrotic tissues and uterine swab cultures obtained at laparotomy revealed T. gondii and C. perfringens, respectively.
Treatment was administered with bactericidal activity against both pathogens. The patient had an uneventful post-operative
recovery. Although there have been some cases which have documented an association between toxoplasmosis and non-uterine
C. perfringens infection, such a relationship has not been established. It is of interest to determine if the presence of both
organisms can explain the severe myonecrosis which occurs in some cases of uterine gas gangrene