Objectives: Tostudyesophagealhighresolutionmanometry(HRM)insystemicsclerosis(SSc)patients
and thecorrelationof findings toTheUniversityofCalifornia,LosAngelesSclerodermaClinicalTrials
Consortiumgastrointestinaltract2.0(UCLASCTC_GIT2.0).
Methods: FortySScpatientswereadministeredtotheUCLASCTCGIT2.0.PatientsunderwentHRMstudy
(Solar GIMMS).HRMdatawerecomparedwith15healthyvolunteers.
Results: Forty patientswithmeanage46 7 7 yearsanddiseaseduration9.3 7 7 yearsreportedupper
(85.7%),lowerGIsymptoms(75%),while5%reportednosymptoms.Mean 7 SD scoresofUCLA
SCTC_GIT2.0itemswereasfollows:reflux 1.2 7 0.8, distention1.6 7 1.2,fecalsoiling0.3 7 0.9,
diarrhea 0.8 7 1,social1 7 1,emotional1 7 1.1,constipation0.5 7 0.9, andtotalGITscore0.9 7 0.6.
Lower esophagealsphincter(LES)pressureanddistalesophagealamplitudeweresignificantly lowerin
SSc patientsthancontrols.Mainmanometric findings weredecreasedLESrestingpressure(40%)and
aperistalsis(40%).RegressionanalysesshoweddistalesophagealamplitudeandLESrestingpressure
negativelycorrelatedwithreflux score(r ¼ −0.64; p ¼ 0.001and r ¼ −0.46; p ¼ 0.019,respectively),
and totalGITscore(r ¼ −0.54; p ¼ 0.007and r ¼ −0.42; p ¼ 0.03, respectively).LESrestingpressurehad
negativecorrelationswithdiarrheascore(r ¼ −0.062; p ¼ 0.002).
Conclusions: Decreased distalesophagealamplitudeencounteredashypoperistalsisorevenaperistalsis
wasassociatedwithincreasedreflux andGITscores(negativelycorrelated)UCLASCTC_GIT2.0
questionnaires.TheGIT2.0iseasytouseandcanserveasanindicatorthatfurthertestingoftheGI
tract, includingtheesophagus,isindicated