Starting with curcumin different pyrane, N-phenyl-1,3-thiazolidin and thiocurcumin derivatives were synthesized. 4-Oxo-3-phenyl1,3-thiazolidin derivative was reacted with different organic reagents examply, benzaldehyde, triethylorthoformate and hydrazine hydrate to form new series of 5-benzylidine-4-oxo-3-phenyl-1,3-thiazolidin, 5-ethoxymethylene-4-oxo-3-phenyl-1,3-thiazolidin and [1,8] naphthyridine derivatives. Some of these derivatives were evaluated as anti- inflammatory agents. All compounds have been characterized by spectral analyses.