For a wide spectrum of pharmacological effects of polyhydroquinolines, this study introduces a developed safe, simple, higher yields and fast method for the synthesis of some new hexahydroquinoline derivatives using one-pot three-component cyclocondensation reaction, via the reaction of 1,3-cyclohexanedione with primary amine and arylidinemalononitrile or salicylaldehyde derivatives. The prepared compounds were reacted with different reagents as N,N-dimethylformamide dimethylacetal, acetic anhydride, ... Read more

The first parent compound N-(7-chloro-5-methyl-1,8-naphthyridine-2- yl)acetamide was reacted with both of ethyl thioglycolate forming ethyl [{7-(acetylamino)-4-methyl-1,8-naphthyridine-2yl} sulfanyl] acetate and ethyl[(-7-amino-4-methyl-1,8- naphthyridine-2yl) sulfanyl] acetate and with thioacetamide to afford N-[5-methyl-7- sulfanyl-1,8-naphthyridine-2-yl] acetamide. The last product was used as an intermediate for the synthesis of different novel mercapto derivatives. The second parent compound 7- amino-2-chloro-4-methyl-1,8-naphthyridine was reacted with several active organic compound ... Read more

The importance of 6-aminocoumarin, D-glucose, and ethyl cyanoacetate in pharmaceutical field was documented in literatures. Therefore, 6-aminocoumarin was reacted with single and double molarity of D-glucose forming Schiff’s base and bis-compound derivatives. Also, it was reacted with CS2 in phase transfer catalysis condition producing dithiocarbamate, which was used as an intermediate for the preparation of fused and polyfused derivatives. Additionally, ... Read more

We report in this study the synthesis of some new N-substituted hexahydro- acridine-1,8-dione compounds including some new N- 2-hydroxypropylhexahydro-acridine-1,8-diones and their tosylatedocta- hydroacridine-1,8-dione derivatives in addition to some bis-hexahydro- acridine-1,8-diones via a one pot reaction technique. Moreover, in vivo anti-inflammatory evaluation for some newly synthesized compounds has been investigated. The highly alkylated bishydroacridine-1,8-dione 5f showed a higher anti- inflammatory potency ... Read more

Regarding to the importance of thieno[2,3-b]thiophens and isothiocyanaetes reactiveties in the physical, chemical and pharmaceutical fields, this study has been undertaken to prepare the target compound 5-cyano-2-carbethoxythieno[2,3-b] thiophenyl-3,4-diisothiocyanates via a safe method. The formed isothio cyanates derivative was reacted with aromatic amines, acid hydrazied and some active methylene groups, followed by cyclization reaction for the formed intermediates to give new ... Read more

Starting with 3,5-diphenylcyclohex-2-en-1-one, 3,5-diphenylcyclohex-2-en-1-semicarbazone,1-chloro-3,5-diphenylcyclohex-2-en-2-carbaldehyde,and3,5-diphenylcyclohex2-en-1-hydrazone were synthesized via the reactions with semicarbazide hydrochloride,POCl3= dimethylformamide, and hydrazine hydrate, respectively. These products were used as key intermediates for the preparation of novel series of tetrahydrobenzothiadiazol-1-oxide, indazole, benzo-thiazepines, pentahydroxyhexylidene and N-thiazines. Some of these derivatives exhibit high antibacterial activityagainst Gram-positive bacteria. Read more

Starting with curcumin different pyrane, N-phenyl-1,3-thiazolidin and thiocurcumin derivatives were synthesized. 4-Oxo-3-phenyl1,3-thiazolidin derivative was reacted with different organic reagents examply, benzaldehyde, triethylorthoformate and hydrazine hydrate to form new series of 5-benzylidine-4-oxo-3-phenyl-1,3-thiazolidin, 5-ethoxymethylene-4-oxo-3-phenyl-1,3-thiazolidin and [1,8] naphthyridine derivatives. Some of these derivatives were evaluated as anti- inflammatory agents. All compounds have been characterized by spectral analyses. Read more

A series of potential biologically active compounds have been synthesized through the derivatization of carboxyl group in Naproxen core structure involving the conversion the Naproxen to its methyl ester then to the acid hydrazide. The acid hydrazide of Naproxen was incorporated with hydrazones, diamide linkage, oxadiazole, pyrazolone, triazole, quinazoline and indole containing motifs. The targeted compounds have been achieved in ... Read more

The title compound, C21H21NO5, crystallizes with two molecules in the asymmetric unit. In each molecule, the central 1,4-dihydropyridine ring adopts a shallow sofa conformations (with the C atom bearing the phenol ring as the flap), whereas the pendant cyclohexene rings both have twisted-boat conformations. Each molecule features an intramolecular O—HO hydrogen bond, which closes an S(8) ring. In the crystal, ... Read more

In the title compound, C23H20ClN3O, each of the cyclohexene and 1,4-dihydropyridine rings of the 1,4,5,6,7,8-hexahydroquinoline ring system adopts a twisted-boat conformation. The dihedral angle between the two benzene rings is 11.52 (7). In the crystal, molecules are linked through a pair of amino–nitrile N—HN hydrogen bonds, forming inversion dimers. These assemble into a three-dimensional network via C—HO and C—H interactions. ... Read more