Objectives: Accurate preoperative detection of lymphatic metastasis may help triaging patients for lymphadenectomy.  Podoplanin is a specific lymphatic marker in immunohistochemical staining. The current study evaluates the correlation between the serum Podoplanin and the lymph node metastasis in gynecologic cancer.

Design: Across-sectional study

Materials and Methods: This study includes 50 cases with gynecologic cancer. For each case a preoperative blood sample for serum Podoplanin is withdrawn and lymphadenectomy is done.

Results: The mean serum Podoplanin was 29 ng/dl in cancer cases without lymph node metastasis and 812 ng/dl in cancer cases with lymph node metastasis. The difference in means was statistically significant. We calculated value of serum Podoplanin more than 140 ng/ml to be suggestive of lymph node metastasis. This cut-off value has a sensitivity, specificity, positive predictive value, negative predictive value, and positive predictive value of 100%, 62%, 93%, and 100% respectively.

Conclusion: Measurement of serum Podoplanin is feasible. The serum Podoplanin is predictive to the presence of lymph node metastasis. This high predictivity need to be reproduced in the future researches.