A SPECTROPHOTOMETRIC meth odfor thedetermi na tion of
can be measured at 464 nm. The decrease in the absorption intensity at
464 nm caused by the presence of the investigated drugs is directly
proportional to their concentration. Investigations were carried out to
study all variables and a validation study for the proposed procedure
according to USP 2002 was also performed. Beer's law was obeyed in
the range of 1-40 ug/ml. The detection limit ranged from 0.22-1.22
ug/ml, while the quantitation limit ranged from 0.73-4.06 ug/ml, The
proposed method was successfully applied for the analysis of the
studied drugs in pharmaceutical preparations with good recoveries in
the range of 98.12-100.02%. Results were compared with those
obtained from the pharmacopoeial or reported methods.