Vitiligo is a common skin disorder that is caused  by selective  destruction of  melanocytes,  resulting in disfiguring loss  of pigment. There  are  convincing  evidences that  cytokines and   T  cell mediate immunity may have a role in its pathogenesis .The present study was conducted to  evaluate  the efficacy   of narrow-band ultraviolet  BUVB) therapy and to determine   some of the immunological   changes in vitiligo by  measuring the serum   levels of soluble interleukin-2 receptor (sIL-2R).  interleukin-6 (IL-6) and tumor necrosis factor-  alpha (INF-a)Serum samples from thirty five patients with  non segmental vitiligo (16 males and J 9 females ) and 20 healthy control subjects were analyzed for serum concentration of  sIL-2R,  ll..-6 and lNF-a..   The  patients  were classified into two  groups according to the course of the diseases. The obtained  results revealed that the serum levels of these cytokines weresignificantly elevated in all patients , progressive ,and st.ationary beforetreatment compared to controls but significant decrease had occurred  for all patients after treatment in comparable with controls ,and there's no significant different between   the levels of cytokines in the localized and generalized    before  and  after   treatment  .In conclusion  these results supports the immunological   theory for the vitiligo  .