Vitiligo is a common skin disorder that is caused by selective destruction of melanocytes, resulting in disfiguring loss of pigment. There are convincing evidences that cytokines and T cell mediate immunity may have a role in its pathogenesis .The present study was conducted to evaluate the efficacy of narrow-band ultraviolet BUVB) therapy and to determine some of the immunological changes in vitiligo by measuring the serum levels of soluble interleukin-2 receptor (sIL-2R). interleukin-6 (IL-6) and tumor necrosis factor- alpha (INF-a)Serum samples from thirty five patients with non segmental vitiligo (16 males and J 9 females ) and 20 healthy control subjects were analyzed for serum concentration of sIL-2R, ll..-6 and lNF-a.. The patients were classified into two groups according to the course of the diseases. The obtained results revealed that the serum levels of these cytokines weresignificantly elevated in all patients , progressive ,and st.ationary beforetreatment compared to controls but significant decrease had occurred for all patients after treatment in comparable with controls ,and there's no significant different between the levels of cytokines in the localized and generalized before and after treatment .In conclusion these results supports the immunological theory for the vitiligo .