Master and MD for anesthesia ,pain management and ICU
nHistorical Perspective
nWhat is General Anesthesia?
nDefinition
nPrinciples of Surgical Anesthesia
nHemodynamic and Respiratory Effects
nHypothermia
nNausea and Vomiting
nEmergence
nOriginal discoverer of general anesthetics
nCrawford Long: 1842, ether anesthesia
nChloroform introduced
nJames Simpson: 1847
nNitrous oxide
nHorace Wells
nMechanisms of Anesthesia
nWilliam Morton
nOctober 16, 1846
nGaseous ether
nPublic demonstration gained world-wide attention
nPublic demonstration consisted of an operating room, “ether dome,” where Gilbert Abbot underwent surgery in an unconscious state at the Massachusetts General Hospital
nEther no longer used in modern practice, yet considered to be the first “ideal” anesthetic
nEarly Ideas
nCellular Mechanisms
nStructures
nMolecular Actions: GABAA Receptor
nMechanism of Propofol (Diprivan®)
nMetabolism and Toxicity
nAdverse Affects of Propofol
nRemaining Questions Concerning the GABAA Receptor
nLatest Discoveries and Current Events