Choose the correct answer for each of the following

  • Growth hormone deficiency
  • Is diagnosed by single blood sample test.
  • Is treated with monthly injection of growth hormone.
  • Is caused by lack of production of growth hormone by the posterior pituitary.
  • Can be excluded if there is advanced bone age for chronological age.
  • Is the most common cause of short stature in children below 2 years of age.

 

  • A baby with XY karyotyping has ambiguous genitalia. The causes to consider are
  • Impaired peripheral androgen metabolism.
  • Pure gonadal dysgenesis (Swyer syndrome).
  • Classic type of congenital adrenal hyperplasia.
  • Kleinfelter syndrome.
  • Complete androgen insensitivity syndrome.

 

  • In congenital adrenal hyperplasia due to 21-hydroxylase deficiency
  • Production of adrenal cortisol is normal.
  • There is incomplete verilization of male genitalia.
  • Associated with low serum androgens level.
  • Diagnosis is made by measuring serum 17-OH-progesterone level.
  • Genital plastic surgery is the only required treatment.

 

  • Concerning central precocious puberty
  • Sex hormone producing gonadal tumour is usually the cause.
  • Menarche is the first sign to appear in girls.
  • Testicular volume is expected to be increased in boys.
  • Serum FSH and LH levels are usually below normal range for age.
  • Treatment with Tamoxifen is indicated in girls.

 

  • Children with type 1 diabetes mellitus usually have
  • Elevated serum C-peptide level.
  • Persistently negative pancreatic islet cell autoantibodies.
  • Acanthosis nigricans.
  • Normal or slightly decreased Body-mass index (BMI) for age.
  • Positive family history of diabetes at young age for 2 or more generations.