Eman Muhammad Salah El-Deen Muhammad Shalabi

Professor - Professor of Pathology

Faculty of medicine

Address: القوصية - محافظة أسيوط


2-Methoxyestradiol Attenuates Angiotensin II-Induced Hypertension, Cardiovascular Remodeling, and Renal Injury
Estradiol may antagonize the adverse cardiovascular effects of angiotensin II (Ang II). We investigated the effects of 2-methoxyestradiol (2-ME), a nonestrogenic estradiol metabolite, on Ang II-induced cardiovascular and renal injury in male rats. First, we determined the effects of 2-ME on Ang II-induced acute changes in blood pressure, renal hemodynamics, and excretory function. Next, we investigated the effects of 2-ME ... Read more

Captopril Attenuates Cardiovascular and Renal Disease in a Rat Model of Heart Failure With Preserved Ejection Fraction
نبذة مختصرة Heart failure with preserved ejection fraction (HFpEF), a prevalent form of heart failure, is frequently accompanied by the metabolic syndrome and kidney disease. Because current treatment options of HFpEF are limited, evaluation of therapies in experimental models of HFpEF with the metabolic syndrome and kidney disease is needed. In this study, we evaluated the effects of captopril, furosemide, ... Read more

HOXB4 Immunoreactivity in Endometrial Tissues From Women With or Without Endometriosis
Endometriosis is a common disease characterized by the presence of ectopic endometrial tissue. Although the pathogenesis of endometriosis remains unclear, several factors have been implicated, including the dysregulation of homeobox (HOX) genes. Our objective was to investigate the localization and immunoreactivity of HOXB4 in endometrial tissues from women with or without endometriosis. We studied samples of eutopic endometrium (EE), endometriomas ... Read more

Epithelial Cell Abnormality in Pap Smear in Women with Postmenopausal Bleeding
Cancer cervix is a preventable and curable disease due to effective screening methods. Uterine cervix is ideal for screening due to easy accessibility for inspection, palpation and exfoliative cytology. The Pap smear is a screening test for cervical cancer, and with appropriate follow-up it can reduce cervical cancer incidence by up to 80%. This study includes fifty peri and postmenopausal ... Read more

2017 | Keywords liver, VEGF,
Vascular endothelial growth factor and hepatic neoangiogenesis in hepatitis C associated chronic liver disease
Worldwide Egypt had the highest prevalence of hepatitis C virus infection. Angiogenesis is a complex process that regulated by many factors, including vascular endothelial growth factor (VEGF). In the liver hepatic satellite cells (HSCs), Kupffer cells, regenerating hepatocytes and existing endothelial cells are responsible for the process of neoangiogenesis and production of vascular endothelial growth factor (VEGF). AIM OF THE ... Read more

2017 | Keywords CD34, liver,
CD34 Expression as a marker of progression of chronic hepatitis C
In Egypt, the rate of death/transplantation, decompensation and HCC in patients with compensated HCV cirrhosis is 4.58%, 6.37% and 3.36%, respectively. It is estimated that Egyptian patients with HCV cirrhosis had an annual incidence of HCC with 5.3%. CD34 is a 110-kDa transmembrane glycoprotein present on leukemic cells, endothelial cells and stem cells). CD34 is preferentially expressed on the surface ... Read more

Expression of β-Catenin in Locally Aggressive Mammary Ductal Carcinoma
Background and Aim: β-catenin is a cell membrane mol-ecule that is essential for cell-cell adhesion of normal epithelia. It is down-regulated in several epithelial tumors and its expression is correlated with tumor cell invasion and metasta-sis. The aim of this study was to evaluate expression status and angiogenic effect of β-catenin in locally aggressive mammary carcinoma. Methods: Formalin-fixed paraffin embedded ... Read more

The use of Desmocollin-2 and Cytokeratin-14 for detection of squamous cell differentiation in urothelial carcinoma
OBJECTIVE To investigate Desmocollin-2 (DSC-2) com pared to Cytokeratin-14 (CK-14) for detection of SquamousCell Carcinoma (SCC) and squamous differentiation of Urothelial Carcinoma (UC) of the urinary bladder METHODS The study included 90 cases of radical cystetomy specimens (69 and 21 ) divided into 35 cases SCC 38 cases UC, 13 cases undifferentiated carcinoma and 4 cases adenocarcinoma. The tissue blocks ... Read more

2016 | Keywords Gouty arthritis, Sonography,
Sonographic Findings in Gouty Arthritis: Diagnostic Value and Association with Disease Duration
The objective of this work was to evaluate the sonographic features of gouty arthritis and correlate findings with disease duration. The study was conducted on 100 patients in ambulatory care aged ≥40 y. Inclusion criteria included mono- or oligo-arthritis with effusion of the knee or the first metatarsophalangeal (MTP) joint and no known history of gout. A complete medical history ... Read more

Dual A1/A2B Receptor Blockade Improves Cardiac and Renal Outcomes in a Rat Model of Heart Failure with Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is prevalent and often accompanied by the metabolic syndrome. Current treatment options are limited. Here we test the hypothesis that combined A1/A2B adenosine receptor blockade is beneficial in obese ZSF1 rats, an animal model of HFpEF with the metabolic syndrome. BG9928, a combined A1/A2B receptor antagonist, was administered orally (10 mg/kg/day) to obese ... Read more