Eman Muhammad Salah El-Deen Muhammad Shalabi

Professor - Professor Emeritus of Pathology

Faculty of medicine

Address: القوصية - محافظة أسيوط


2020 | Keywords Endometrial Carcinoma, Ezrin,
A Potential Invasion-Promoting Role for Ezrin in Endometrial Carcinoma.
Abstract Background:Ezrin is a cell membrane-cytoskeleton linker that is essential to maintain the normal cell shape and the integrity of cell-cell adhesion. Overexpression of ezrin is correlated with poor prognosis in several malignancies. Aim:To evaluate the expression of ezrin in hyperplastic and neoplastic endometrial tissues and to correlate its expression with the clinical and pathological parameters of endometrial carcinoma. Methods:Tissue ... Read more

2020 | Keywords FNAC, Thyroid Lesions,
Evaluation of Thyroid Lesions Using Fine Needle Aspiration Cytology
Background: Discrete thyroid swelling is common clinical presentation with prevalence rate of 4-7% in the general population. Now fine needle aspirate cytology (FNAC) is very important technique fordiagnosis of thyroid nodules, as it is very simple, safe, less invasive technique.Objective:To evaluate the diagnostic accuracy ofFNAC inThyroid Nodules.Patients and Methods:Study carried out on patients who visited the Outpatient Clinic of General ... Read more

2020 | Keywords Membranous Nephropathy, Phosph,
Detection of Phospholipase A2 Receptor Related Membranous Nephropathy in Membranous Nephropathy Patient.
Background: Membranous glomerulonephritis (MGN) considered as the most common causes of nephrotic syndrome (NS) in the world. Eighty percent of cases are classified as primary MGN. Primary MGN is an autoimmune disease in which autoantibodies against podocyte antigens forming subepithelial immune deposits and result in NS. Autoantibodies against M-type phospholipase A2 receptor (PLA2R) were found in 70-80% of patients with ... Read more

2020 | Keywords βCatenin, Urothelial carcinoma,
Immunohistochemical expression of β-Catenin in urinary bladder urothelial carcinoma.
Background:Bladder cancer is the ninth common cancer in the world, the third common cancer among men in the Arabic and Western Asian countries. In Egypt, UC has become the most frequent type with its incidence rising from 16% to 65.8%. Tumorgrade and stage have been shown to have a strong correlation with tumor recurrence and progression to invasive bladder cancer. ... Read more

2020 | Keywords P63, Ophthalmic Pterygium,
Immunohistochemical Expression of p63 in Ophthalmic Pterygium.
Background: Pterygium is one of the most commonly occurring eye diseases. It is widely regarded as a degenerative condition. Pterygium shares some similarities with tumors, as active cell proliferation.. P63, a member of the p53 gene family is a transcription factor that is crucial for the development and maintenance of stem cells in stratified epithelia. It is present in the ... Read more

2020 | Keywords MMP-9, meningioma,
Immunohistochemical expression of matrix metalloproteinase -9 in invasive meningioma.
Background: Meningioma is a common intracranial tumor arising from the meningothelial (arachnoid) cells. Meningiomas are divided into 15 histological subtypes and three grades, including benign (grade I), atypical (grade II) and anaplastic (grade III).It is important to correctly decide whether a meningioma isbrain-invasive or not.Tumor invasion can be described as a stepwise process involving the degradation of the extracellular matrix ... Read more

2020 | Keywords E-cadherin, Breast Carcinoma,
Immunohistochemical Expression of E-cadherin in Invasive Duct Carcinoma of the Breast.
Breast cancer is the most frequent malignant tumor in women worldwide. E-Cadherin is a calcium-dependent epithelial cell adhesion molecule that is expressed at adherens junctions. Its loss may result in a poorly differentiated tumorphenotype. Cells with mutated E-cadherin demonstrate increased motility,altered organization of their actin cytoskeletonandassociated with metastases, thereby providing evidence for its role as an invasion suppressor. Objectives:Assess the ... Read more

2020 | Keywords H. pylori , Lymphocytes,
Lymphocytic infiltration in Helicobacter pylori gastritis.
Background: Severity of lymphocytic infiltration to gastric mucosa is a good indicator for severity ofH.Pylori gastritisObjectives: To evaluate the lymphocytic infiltration in the gastric mucosa associated with H.Pylori infection.Patients and Method(s): This study done on 50 cases with chronic gastritis and H.Pylori were detected by using geimsa stain with evaluation of degree of lymphocytic infiltrationResults: H.Pylori infection was detected in ... Read more

2-Methoxyestradiol Attenuates Angiotensin II-Induced Hypertension, Cardiovascular Remodeling, and Renal Injury
Estradiol may antagonize the adverse cardiovascular effects of angiotensin II (Ang II). We investigated the effects of 2-methoxyestradiol (2-ME), a nonestrogenic estradiol metabolite, on Ang II-induced cardiovascular and renal injury in male rats. First, we determined the effects of 2-ME on Ang II-induced acute changes in blood pressure, renal hemodynamics, and excretory function. Next, we investigated the effects of 2-ME ... Read more

2019 | Keywords Nestin, gliomas, stem cell,
Immunohistochemical expression of Nestin as Cancer Stem Cell Marker in gliomas
Background: Gliomas represent the most frequent primary tumors of central nervous system (CNS), contributing to more than half of the incidence of brain tumors. Cancer stem cell markers (CSC) identify a group of patients at high risk for progression. Nestin is an intermediate filament (IF) protein was first described as a neural stem cell/progenitor cell marker. Nestin-positive neuroepithelial stem cells ... Read more