eman_shalabi

Eman Muhammad Salah El-Deen Muhammad Shalabi

Professor - Professor Emeritus of Pathology

Faculty of medicine

Address: القوصية - محافظة أسيوط

23

Like
28 28 28 112 7 32 1.6K 5.3K
242

Newly Added
  • Courses 28
  • Course Supplements 28
  • Courses Tasks 28
  • Publications 112
  • Office hours 7
  • Announcements 32
  • File uploaded 150
  • Downloaded Times 69

Diverticular disease: Is it an underestimated problem in our locality?

2004 | Keywords our locality, Diverticular disease,
Diverticular disease: Is it an underestimated problem in our locality?
ABSTRACT BACKGROUND: Colonic diverticular disease is common in Western countries. It is often asymptomatic; only 10-26% of patients will progress to diverticulitis with symptoms ranging from minor complaints to life threatening sequelae. OBJECTIVES: To recognize the pattern of presentation, diagnosis, treatment and outcome of diverticular disease in our community. METHODS: From January 1996 to June 2004, 19 patients with diverticular ... Read more

Immunohistochemical Study, In Situ Hybridization and Computerized Image Analysis of Colorectal Epithelial Progression from Adenoma to Carcinoma

2004 | Keywords Carcinoma, adenoma, Colorectal, ApopTag, Ki-67., P53, Bax, Bcl-2,
Immunohistochemical Study, In Situ Hybridization and Computerized Image Analysis of Colorectal Epithelial Progression from Adenoma to Carcinoma
SUMMARY: Adenoma-carcinoma sequence was postulated for most colorectal carcinomas. Deregulation of apoptosis and cellular proliferation is involved in the pathogenesis of neoplasia. The apoptotic genes that have been characterized in colon cancer are bcl-2, bax, and p53. Studying the expression of these genes and of the proliferating cell marker (Ki-67) in adenoma carcinoma sequence well be of great value in ... Read more

Apoptosis and Colorectal Carcinoma; a Multiparameter Immunohistochemical, and Computerized Image Analysis Study

2003 | Keywords Carcinoma, Colorectal, ApopTag, Ki-67, P53, Bax, Bcl-2,
Apoptosis and Colorectal Carcinoma; a Multiparameter Immunohistochemical, and Computerized Image Analysis Study
ABSTRACT: The last few years showed an increase in the incidence of the colorectal cancer in Egypt. Between 20% and 50% of patients with this cancer are susceptible to death within five years of diagnosis. Tumor growth results from a disturbance in the balance between the rates of cell proliferation and cell death (apoptosis). We studied the expressions of proteins ... Read more

2-Hydroxyestradiol Attenuates Renal Disease in Chronic Puromycin Aminonucleoside Nephropathy

2002 | Keywords 2-Hydroxyestradiol, Renal Disease, Chronic Puromycin Aminonucleoside Nephropathy,
2-Hydroxyestradiol Attenuates Renal Disease in Chronic Puromycin Aminonucleoside Nephropathy
ABSTRACT It has been previously shown that 2-hydroxyestradiol (2-OHE) attenuates the development of renal disease in genetic nephropathy associated with obesity and the metabolic syndrome. The purpose of this study was to test the hypothesis that 2-OHE, irrespective of its effects on metabolic status and/or obesity, exerts direct renoprotective effects _in vivo_. First, the effects of increasing doses of 2-OHE ... Read more

Peutz Jegher hamartomatous polyps: How it progress to cancer?

2002 | Keywords cancer, polyps, Peutz Jegher,
Peutz Jegher hamartomatous polyps: How it progress to cancer?
ABSTRACT: Peutz-Jegher Syndrome (PJS) is an autosomal dominant inherited disease, characterized by gastrointestinal (GI) hamartomatous polyps frequently associated with GI and non-GI tumors, leading to reassessment of cancer risk in this lesion. Another type of hamartomatous polyps, the hyperplastic polyps, is common in the colon and in its pure form carries no risk of malignancy, whereas adenomas of the colon ... Read more

Comparative study of Bcl-2, Bax, p53, STAT3 and β-catenin and their relationship to colonic epithelial progression from adenomas to carcinomas: a multiparameter immunohistochemical computerized image analysis study

2002 | Keywords Bcl-2, Bax, P53, STAT3, β-Catenin, COLON, adenoma, Carcinoma,
Comparative study of Bcl-2, Bax, p53, STAT3 and β-catenin and their relationship to colonic epithelial progression from adenomas to carcinomas: a multiparameter immunohistochemical computerized image analysis study
ABSTRACT: Adenoma-carcinoma sequence was postulated for most colorectal carcinomas. Deregulation of apoptosis & cell proliferation is involved in the pathogenesis of neoplasia. The apoptosis genes characterized in colon cancer are bcl-2, bax & p53. b-catenin plays a role in both cell adhesion & intracellular signaling. Translocation of b-catenin from the cell membrane to the cytoplasm or nucleus is an early ... Read more

Markers defining colorectal adenoma-carcinoma progression: a computerized image analysis protocol

2002 | Keywords Colorectal cancer, adenoma, Carcinoma, , Bcl-2, Bax , P53, Ki-67, , ApopTag, , β-Catenin,
Markers defining colorectal adenoma-carcinoma progression: a computerized image analysis protocol
ABSTRACT: The vast majority of colorectal carcinoma are widely believed to arise from polypoid adenomas. The apoptotic related genes that have been most consistently characterized in colonic cancer are bcl-2, bax, and p53. Studying the expression of these genes in adenoma carcinoma sequence will be of great value in producing the clinical behavior of benign tumors. Loss of contact inhibition ... Read more

Basal cell hyperplasia (BCH) versus High grade prostatic Intraepithelial neoplasia (HGPIN) in tiny prostatic needle biopsies: Unusual diagnostic dilemma

| Keywords BCH, HGPIN,
Basal cell hyperplasia (BCH) versus High grade prostatic Intraepithelial neoplasia (HGPIN) in tiny prostatic needle biopsies: Unusual diagnostic dilemma
_BACKGROUND_: Histopathological differentiation between BCH and HGPIN in prostatic needle biopsies is a diagnostic challenge. The gold standard for detection of HGPIN and BCH is histopathological examination; however subjectivity in interpretation and tiny volume of obtained tissue hamper reliable diagnosis. _AIMS_: The aim of this study was to assess usefulness of using the p63 and P504s to solve this problem. ... Read more

Immunohistochemical Study of iNOS in Peritoneal Tuberculous Granuloma

| Keywords 2007, Tuberculous Granuloma, Peritonium, iNOS, Immunohistochemistry,
Immunohistochemical Study of iNOS in Peritoneal Tuberculous Granuloma
ABSTRACT BACKGROUND: The human tuberculous granuloma provides the morphological basis for local immune processes central to the outcome of tuberculosis. Nitric Oxide (NO), produced by the inducible nitric oxide synthase (iNOS), is important in host defense against Mycobacterium tuberculosis in rodents, but the presence of high-output NO production in human tuberculosis has been controversial. Because of the scarcity of information ... Read more

Estradiol metabolites attenuate renal and cardiovascular injury induced by chronic nitric oxide synthase inhibition

| Keywords 2005, chronic nitric oxide, cardiovascular, renal, Estradiol,
Estradiol metabolites attenuate renal and cardiovascular injury induced by chronic nitric oxide synthase inhibition
ABSTRACT: Our previous studies in rodent models of nephropathy demonstrate that 2-hydroxyestradiol (2HE), an estradiol metabolite with little estrogenic activity, exerts renoprotective effects. In vivo, 2HE is readily converted to 2-methoxyestradiol (2ME), a major estradiol metabolite with no estrogenic activity. The goal of this study was to determine whether 2ME has renal and cardiovascular protective effects in vivo. First, the ... Read more