Eman Muhammad Salah El-Deen Muhammad Shalabi

Professor - Professor Emeritus of Pathology

Faculty of medicine

Address: القوصية - محافظة أسيوط



Publications Which contain the keyword: Bax

2018-10-22 21:36:49 Keywords Carcinoma, adenoma, Colorectal, ApopTag, Ki-67., P53, Bax, Bcl-2,
Immunohistochemical Study, In Situ Hybridization and Computerized Image Analysis of Colorectal Epithelial Progression from Adenoma to Carcinoma
SUMMARY: Adenoma-carcinoma sequence was postulated for most colorectal carcinomas. Deregulation of apoptosis and cellular proliferation is involved in the pathogenesis of neoplasia. The apoptotic genes that have been characterized in colon cancer are bcl-2, bax, and p53. Studying the expression of these genes and of the proliferating cell marker (Ki-67) in adenoma carcinoma sequence well be of great value in ... Read more

2018-10-22 22:17:49 Keywords Carcinoma, Colorectal, ApopTag, Ki-67, P53, Bax, Bcl-2,
Apoptosis and Colorectal Carcinoma; a Multiparameter Immunohistochemical, and Computerized Image Analysis Study
ABSTRACT: The last few years showed an increase in the incidence of the colorectal cancer in Egypt. Between 20% and 50% of patients with this cancer are susceptible to death within five years of diagnosis. Tumor growth results from a disturbance in the balance between the rates of cell proliferation and cell death (apoptosis). We studied the expressions of proteins ... Read more

2018-10-16 15:17:40 Keywords Bcl-2, Bax, P53, STAT3, β-Catenin, COLON, adenoma, Carcinoma,
Comparative study of Bcl-2, Bax, p53, STAT3 and β-catenin and their relationship to colonic epithelial progression from adenomas to carcinomas: a multiparameter immunohistochemical computerized image analysis study
ABSTRACT: Adenoma-carcinoma sequence was postulated for most colorectal carcinomas. Deregulation of apoptosis & cell proliferation is involved in the pathogenesis of neoplasia. The apoptosis genes characterized in colon cancer are bcl-2, bax & p53. b-catenin plays a role in both cell adhesion & intracellular signaling. Translocation of b-catenin from the cell membrane to the cytoplasm or nucleus is an early ... Read more

2018-10-02 13:04:20 Keywords Bcl-2, Bax, HCV,
The Role of Bcl-2 and Bax as Markers of Disease Progression in Hepatitis C Virus Infected Patients
Many apoptotic markers have been linked to hepatic cell injury in HCV-related liver diseases, and hence could be used as potential markers for early detection of the disease. The present study aimed to assess the role of apoptotic markers Bcl-2 and Bax in the pathogenesis of chronic HCV-related liver diseases. A total of 85 participants were enrolled into the study; ... Read more

2018-09-12 15:34:13 Keywords o breast, DCIS, Bcl-xl, Bax, Bcl-2, P53,
Expression of p53, bcl-2, bax and bcl-xl in ductal carcinoma in situ (DCIS) of the breast.
BACKGROUND: DCIS is a malignant proliferation of mammary ductal epithelial cells without invasion beyond the basement membrane. Bcl-2, bax, bcl-xl and p53 are implicated in regulation of apoptosis. This study aimed to clarify the role of these gene products in DCIC. MATERIALS AND METHODS: Immunohistochemical staining of 13 cases of DCIS with bcl-2, bax, bcl-xl and p53 was performed. RESULTS: ... Read more

2018-09-06 09:17:46 Keywords Breast Carcinoma, Bax, Bcl-2,
Evaluation of Immunohistochemical Anti-apoptotic Bcl-2 and Pro-apoptotic Bax Gene Products in Breast Carcinoma
One of the greatest challenges in breast cancer management is to accurately predict the outcome for each patient. To do this at present, we rely heavily on traditional pathological variables, such as tumor size, tumor grade and lymph node status. However, despite the broad applicability of clinico-pathological indices, they are still unable, to separate the 30% node-negative patients who will ... Read more

2018-09-06 09:20:17 Keywords Apoptosis, Breast Carcinoma, Bax, Bcl-xl,
Studying of Apoptosis in Breast Carcinoma; Immunohistochemical Evaluation of Pro- and Anti-apoptotic Gene Products Bax and Bcl-xl
Cancer cells acquire their hallmarks of malignancy through the accumulation of gene activation and inactivation over long periods of time. Gene expression studies offer the greatest promise for refining prognostication in breast cancer. For breast cancer, this multistep process may manifest itself as a sequence of pathologically defined stages. Dys-regulation of apoptosis overrides many of the normal checkpoint pathways and ... Read more

2018-09-08 00:09:25 Keywords squamous cell carcinoma, Larynx, Bax, Bcl- Bcl-xL, Survivin,
Expression of Survivin, Bcl-xL and Bax in Laryngeal Squamous Cell Carcinoma; A Clinicopathological Study
ABSTRACT Laryngeal squamous cell carcinoma (SCC) is the most frequent tumor of head and neck region. Survivin (SVV) is one of the inhibitors of apoptosis which is over-expressed in almost all malignancies but rarely detected in normal differentiated adult tissues. Bcl-XL and Bax are members of a family of proteins that regulate apoptosis. In contrast to Bcl-XL that inhibits apoptosis ... Read more

2018-09-08 11:33:46 Keywords Apoptosis, esophagealus, Esophagus, P53, Bax, squamous cell carcinoma,
Expression of apoptosis-regulating proteins p53, and bax in primary  resected esophageal squamous cell carcinoma
ABSTRACT Currently, clinico-pathological staging and classification of residual tumor are the most important prognostic factors for clinical outcome in esophageal cancer. Nevertheless, patients with similar stages of the disease show a marked discrepancy in survival. Several new molecular prognostic factors are being evaluated in the hope that they may contribute to better assessment of the survival probability and, consequently, the ... Read more

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