Dr.ramykamal

Ramy Kamal Amin Sayed

Lecturer - Lecturer of Veterinary Anatomy and Embryology

Faculty of Veterinary Medicine

Address: Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Sohag University

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Retinoid-related orphan nuclear receptor alpha- (RORα-) deficient mice display morphological testicular defects

2019 | Keywords
Retinoid-related orphan nuclear receptor alpha- (RORα-) deficient mice display morphological testicular defects
The role of retinoid-related orphan receptor, one of the transcription factors reported in testis, in testicular function is unclear, so this study was performed to evaluate the qualitative and quantitative changes in the testicular structure of RORα-deficient mice using light-, electron-microscopy, and immunohistochemistry. Among the most striking alterations observed in the testis of the mutant mice were hypospermatogenesis, marked reduction ... Read more

β-RA reduces DMQ/CoQ ratio and recues the encephalopathic phenotype in Coq9R239X mice

2019 | Keywords , 4-dihydroxybenzoic acid, 2, 4-dihydroxybenzoic acid, astrogliosis, mitochondrial encephalopathy, Q synthome, spongiosis,
β-RA reduces DMQ/CoQ ratio and recues the encephalopathic phenotype in Coq9R239X mice
Coenzyme Q (CoQ) deficiency has been associated with primary defects in the CoQ biosynthetic pathway or to secondary events. In some cases, the exogenous CoQ supplementation has limited efficacy. In the Coq9R239X mouse model with fatal mitochondrial encephalopathy due to CoQ deficiency, we have tested the therapeutic potential of b-resorcylic acid (b-RA), a structural analog of the CoQ precursor 4-hydroxybenzoic ... Read more

Lack of NLRP3 inflammasome activation reduces age-dependent sarcopenia and mitochondrial dysfunction, favoring the prophylactic effect of melatonin

2019 | Keywords NLRP3 inflammasome, Frailty, ultrastructure, Mitochondria, Sarcopenia, Gastrocnemius muscle,
Lack of NLRP3 inflammasome activation reduces age-dependent sarcopenia and mitochondrial dysfunction, favoring the prophylactic effect of melatonin
To investigate the role of NLRP3 inflammasome in muscular aging, we evaluated here the morphological and functional markers of sarcopenia in the NLRP3-knockout mice, as well as the beneficial effect of melatonin supplementation. The gastrocnemius muscles of young (3 months), early-aged (12 months), and old-aged (24 months) NLRP3-knockout female mice were examined. Moreover, locomotor activity and apoptosis were assessed. The ... Read more

The protective effect of melatonin against age-associated sarcopenia-dependent tubular aggregates formation, lactate depletion and mitochondrial changes

2018 | Keywords Aging, Apoptosis, autophagosome, melatonin, gastrocnemius, Sarcopenia,
The protective effect of melatonin against age-associated sarcopenia-dependent tubular aggregates formation, lactate depletion and mitochondrial changes
To gain insight into the mechanism of sarcopenia and the protective effect of melatonin, the gastrocnemius muscles of young (3-4 months), early-aged (12 months), and old-aged (24 months) wild type C57BL/6J female mice, were examined by magnetic resonance and microscopy. Locomotor activity, lactate production and nuclear apoptosis were also assessed. The results support the early onset of sarcopenia at 12 ... Read more

In Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy

2018 | Keywords in vivo respiration, ETS capacity, proton leak, zebrafish embryos, melatonin,
In Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy
Although mitochondria dysfunction is related to multiple diseases, no in vivo studies are available on mitochondrial respiration in animal parkinsonian models. Our aim is to analyze in vivo mitochondrial respiration, which reflects changes in mitochondrial bioenergetics more precisely than in vitro mitochondrial preparations. These experiments can be carried out in zebrafish embryos, which were treated with 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) from ... Read more

Assessment of date palm pollen supplementation on productivity, digestibility, immune response, and intestinal and hepatic morphology of Egyptian fayoumi laying Hens

2018 | Keywords date palm pollen, digestibility, immune response, intestinal morphology, liver,
Assessment of date palm pollen supplementation on productivity, digestibility, immune response, and intestinal and hepatic morphology of Egyptian fayoumi laying Hens
This study was carried out to assess the influence of date palm pollen supplement on the productive performance, digestibility, immune response, and some morphological parameters of Fayoumi laying hens. One-hundred and fifty hens of 30-weeks of age were included in the study. The treated group was supplemented with 0.5% date palm pollen. The experiment was divided into three periods; each ... Read more

Behavioral, hepato-morphological, and biochemical studies on the possible protective effect of black seed and water bath against change-mediated heat stress on pigeon

2018 | Keywords wheat, Propolis, Hepatocytes, Glucose, Catalase, ANTIOXIDANT,
Behavioral, hepato-morphological, and biochemical studies on the possible protective effect of black seed and water bath against change-mediated heat stress on pigeon
Background: Heat stress condition (34 °C, Egyptian summer season) in pigeon leads to a lot of negative impacts on behavior, physiology, hepatic architecture, and biochemical parameter changes. The aim of this study was to evaluate the effect of water bath as a managerial and low-quality diet (wheat) as well as some feed additives (propolis or black seed) as nutritional factors ... Read more

Melatonin enhances the toxicity of radio-and chemotherapy in head and neck cancer cells

2017 | Keywords Cancer cells, Chemotherapy, melatonin, radiotherapy,
Melatonin enhances the toxicity of radio-and chemotherapy in head and neck cancer cells
After reported a melatonin’s gel that protects normal cells from oral mucositis induced by radio- or chemotherapy, we wondered about how melatonin affects tumoral cells. It is well known that both radio- and chemotherapy act at different intracellular levels such as nucleus, membranes and mitochondria. On the other hand, mitochondrion is the main melatonin target. So we evaluated here whether ... Read more

CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome

2017 | Keywords Blood pressure, COX, glutathione, mitochondrial disease, SQR,
CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome
Coenzyme Q (CoQ) is a key component of the mitochondrial respiratory chain, but it also has several other functions in the cellular metabolism. One of them is to function as an electron carrier in the reaction catalyzed by sulfide:quinone oxidoreductase (SQR), which catalyzes the first reaction in the hydrogen sulfide oxidation pathway. Therefore, SQR may be affected by CoQ deficiency. ... Read more

Macro and Microanatomical Studies on the Choanal Slit of Turkey (Meleagris gallopavo)

2017 | Keywords Choana, SEM, Palatine salivary glands, Palatine ridge, morphology,
Macro and Microanatomical Studies on the Choanal Slit of Turkey (Meleagris gallopavo)
This work was carried out to describe the morphological characteristics of the choanal slit of the turkey through gross, light, and scanning electron microscopy. The choanal slit measures 27.62 mm long, and constitutes 38.30 % of the total length of the palate. The edges of the narrow part of the choanal slit is smooth rostrally but slightly thickened caudally due ... Read more