Background: DCIS is a malignant proliferation of mammary ductal epithelial cells without invasion beyond the basement membrane. Bcl-2, bax, bcl-xl and p53 are implicated in regulation of apoptosis. This study aimed to clarify the rokle of these gene products in DCIS. Patients and methods: Immunohistochemical staining of 13 cases of DCIS with bcl-2, bax, bcl-xl and p53 was performed. Results: ... Read more

Objectives Our aim was to explain the spectrum of clinical and CT findings in 18 patients with acute epiploic appendagitis. Methods and Materials We reviewed the clinical records and CT pictures of 18 consecutive patients seen in Nejran Armed Forces Hospital, Nejran, Kingdom of Saudi Arabia and Sohag University Hospital, Sohag, Egypt between July 2006 and June 2013 with a ... Read more

Objectives: To study the appropriate method of diagnosis and management in adult intussusception (AI) focusing on the clinical manifestations, diagnostic tools, and management of this rare disease. Methods: This retrospective study reviewed and analyzed the demographic data, clinical features, diagnosis, management, and pathology reports of all adult patients (18 years of age and older) with a diagnosis of intussusception admitted ... Read more

Introduction: The ideal management of common bile duct (CBD) stones is preoperative endoscopic retrograde cholangiopancreatography (ERCP) and extraction of stones followed by laparoscopic cholecystectomy (LC) which should be safe and cost effective. The time interval between ERCP and LC is a matter of debate. Aim: To evaluate the effect of time interval between ERCP and LC in patients with calcular ... Read more

Purpose: Intra abdominal and pelvic fluid collection is a serious problem that requires drainage. The goal of our study was to report our experience and evaluate the feasibility, safety and outcome of percutaneous image-guided aspiration versus catheter drainage of abdominal and pelvic collections. Patients and methods: This is a retrospective study of 84 patients (45 males and 39 females of ... Read more

Gastric outlet obstruction (GOO) is not considered a single entity; rather it is the clinical consequence of any disease process that produces blockade to gastric emptying. A study shows that only 37% of patients with GOO have benign disease and the remaining patients have obstructions due to malignancy. Gossypibomas most commonly occur following abdominal and gynecological surgery and generally require ... Read more

Background: P53 is a tomour suppressor gene that plays a critical role in preventing human cancer formation. In response to a variety of of stress signals p53 becomes activated and induces cell cycle arrest and/or apoptosis. We Aimed to: 1. study the immunohistochemical profileof p53 in breast carcinoma (BC). 2. Assess its prognostic value in relation to clinico-pathological prognostic factors ... Read more

Introduction: Laparoscopic ventral and incisional hernia repair (LVIHR) is a challenging procedure, but it has the potential to improve outcomes for the management of ventral and incisional hernias. The aim of this prospective study was to evaluate its short and intermediate-term outcome. Patients and Methods: 28 patients presented to our hospital with non-complicated ventral and incisional hernias were given the ... Read more

Cancer cells acquire their hallmarks of malignancy through the accumulation of gene activation and inactivation over long periods of time. Gene expression studies offer the greatest promise for refining prognostication in breast cancer. For breast cancer, this multistep process may manifest itself as a sequence of pathologically defined stages. Dys-regulation of apoptosis overrides many of the normal checkpoint pathways and ... Read more

Introduction: This study assessed the periareolar incision as a versatile approach for the removal of palpable benign breast masses and measured objectively its aesthetic outcome. Methods: This prospective study included 44 adult patients with clinically and radiologically suspected palpable benign breast masses which were excised through the periareolar incision. It was done at the Plastic and General Surgery Departments, kasr ... Read more