Synthesis of Some New 1,8-Naphthyridines From N-(7-Chloro-5-Methyl-1,8-Naphthyridine-2-yl) Acetamide and 7-Amino-2-Chloro-4-Methyl-1,8-Naphthyridine
The first parent compound N-(7-chloro-5-methyl-1,8-naphthyridine-2- yl)acetamide was reacted with both of ethyl thioglycolate forming ethyl [{7-(acetylamino)-4-methyl-1,8-naphthyridine-2yl} sulfanyl] acetate and ethyl[(-7-amino-4-methyl-1,8- naphthyridine-2yl) sulfanyl] acetate and with thioacetamide to afford N-[5-methyl-7- sulfanyl-1,8-naphthyridine-2-yl] acetamide. The last product was used as an intermediate for the synthesis of different novel mercapto derivatives. The second parent compound 7- amino-2-chloro-4-methyl-1,8-naphthyridine was reacted with several active organic compound ... Read more