Diabetic nephropathy (DN) is a major cause of end-stage renal disease. Yet the pathogenic mechanisms underlying the development of DN are not fully defined, partially due to lack of suitable models that mimic the complex pathogenesis of renal disease in diabetic patients. In this study, we describe early and late renal manifestations of DN and renal responses to long-term treatments ... Read more

Oxidative stress plays a crucial role in tissue damage occurring in diabetes mellitus (DM). A number of studies reported that antioxidants can attenuate the complications of DM. The present study was undertaken to study the histopathological and biochemical effects of oxidative stress on hepatic and renal tissue in streptozotocin-induced DM in rats, and to evaluate the role of enalapril and ... Read more