The purpose of this study was to identify sites of squamous differentaion in urothelial carcinoma of the urinary bladder, to differntaite between urothelial carcinoma and squmaous cell carcinoma of the urinary baldder specially those poorly  differntiated forms using DSC-2, COX-2 and CK-14 and to corelate these markers with avilalable clinical and histological parameters in urinary bladder