eman_shalabi

Eman Muhammad Salah El-Deen Muhammad Shalabi

Professor - Professor Emeritus of Pathology

Faculty of medicine

Address: القوصية - محافظة أسيوط

23

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2010 | Keywords Children, enlarged liver, liver biopsy, PLV,
Percutaneous guided liver biopsy  in the diagnosis of chronic unexplained enlarged liver in children in upper Egypt
Percutaneous guided liver biopsy (PLB) is the standard procedure for obtaining hepatic tissue for histopathological examination, and remains an essential tool in the diagnosis and management of the exact pattern and extent of parenchymal liver diseases. This a prospective hospital based study was conducted during the period from April 2008 till June 2010 at Pediatric Department of Assiut University Hospital ... Read more

Ki-67 and Osteocalcin Immunostaining Expression in Osteogenic Tumors; Osteoblastoma and Osteosarcoma
_BACKGROUND/AIMS:_ Osteoblastoma and osteosarcoma are primary bone forming tumors that show different radiological/pathological features and clinical behavior. This study aims to specify the expression profile of Ki-67 and osteocalcin in osteoblastomas and osteosarcomas._METHODS:_Ki-67 and osteocalcin immunoexpression were studied in 9 osteoblastomas and 30 osteosarcomas; including 27 osteoblastic osteosarcomas._RESULTS:_There was gradual significant increase (pCONCLUSION:_ Ki-67 increased ongoing from osteoblastomas through low ... Read more

Non-Invasive Assessment of Liver Fibrosis in Chronic Hepatitis C Patients
BACKGROUND: The gold standard for assessment of liver fibrosis is liver biopsy, which is invasive and may rarely results in complications. Therefore, searching for alternative, accurate non-invasive parameters to evaluate the presence and degree of liver fibrosis is needed for prediction of prognosis and planning treatment of chronic hepatitis C (CHC) patients AIM: To examine if serum laboratory markers combined ... Read more

2010 | Keywords diagnosis of breast masses, TCNB, FNAC,
Comparitive study between FNAC and TCNB for diagnosis of breast masses
Most diseases of the breast present as a palpable mass. The majority of breast lesions are not malignant, and most benign lesions do not progress to cancer; however the accuracy of diagnosis can be increased by a combination of preoperative tests like physical examination, mammography, fine-needle aspiration cytology (FNAC), and Tru cut needle biopsy (TGNB) or core needle biopsy (CNB). ... Read more

Expression of Survivin, Bcl-xL and Bax in Laryngeal Squamous Cell Carcinoma; A Clinicopathological Study
ABSTRACT Laryngeal squamous cell carcinoma (SCC) is the most frequent tumor of head and neck region. Survivin (SVV) is one of the inhibitors of apoptosis which is over-expressed in almost all malignancies but rarely detected in normal differentiated adult tissues. Bcl-XL and Bax are members of a family of proteins that regulate apoptosis. In contrast to Bcl-XL that inhibits apoptosis ... Read more

Investigation of the Role of Vaccinia Virus VH1-Related (VHR) in Progression of Cervical Carcinoma
ABSTRACT BACKGROUND: Vaccinia virus VH1-related (VHR) dual-specific protein phosphatase, encoded by the _DUSP3 _gene, has been reported to play a critical role in cell cycle progression. Recent studies have demonstrated that lack of VHR expression by cells causes their arrest in G1 and G2 phases of the cell cycle also they showed early signs of cell senescence. The usefulness of ... Read more

2009 | Keywords Breast Carcinoma, Bax, Bcl-2,
Evaluation of Immunohistochemical Anti-apoptotic Bcl-2 and Pro-apoptotic Bax Gene Products in Breast Carcinoma
One of the greatest challenges in breast cancer management is to accurately predict the outcome for each patient. To do this at present, we rely heavily on traditional pathological variables, such as tumor size, tumor grade and lymph node status. However, despite the broad applicability of clinico-pathological indices, they are still unable, to separate the 30% node-negative patients who will ... Read more

Immunohistochemical Study of Inducible Nitric Oxide Synthase "iNOS" in Peritoneal Tuberculous Granuloma
Background/Aim: Nitric Oxide (NO) is important in host defense against Mycobacterium tuberculosis in rodents, but the presence of high-output NO production in human tuberculosis has been controversial. This study aimed to investigate iNOS expression by peritoneal macrophages in TB peritonitis and to gain insights into the structural properties of peritoneal TB granuloma. Patients and Methods: Peritoneal biopsies were obtained from ... Read more

2008 | Keywords Immune Cells, TB,
Immunohistochemical analysis of the immune cells in  the epithelioid cell granuloma of tuberculoid leprosy
BACKGROUND: THE THE EPITHELIOD CELL GRANULOMA IS THE HALLMARK OF TUBERCULOID LEPROSY (TL). IN THIS INVESTIGATION, WE TRIED TO CHARACTRIZE THE CELL POPULATION IN THESE GRANULOMAS MATERIALS AND METHODS:GRANULOMA CELL POPULATION WAS IMMUNOHISTOLOGICALLY EXAMINED IN 30 CASES OF UNTREATED TL AND FIVE ADDITIONAL CONTROL CASES WITH NORMAL SKIN (IMMUNOPEROXIDASE STAINING METHODS) USING ANTIBODIES TARGETING ANTIGENS FOR B CELLS (CD20+), T ... Read more

2008 | Keywords diabetic renal,
Renal and metabolic effects of tempol in obese ZSF1 rats--distinct role for superoxide and hydrogen peroxide in diabetic renal injury
Oxidative stress, that is, overproduction of reactive oxygen species and reduced antioxidant system activity, is implicated in the pathogenesis of diabetic complications; and therefore, superoxide dismutase (SOD) mimetic tempol should be protective in diabetic kidney. However, the effects of tempol in metabolic syndrome-associated renal injury have not been thoroughly examined. In this study, we examined the effects of 9 weeks ... Read more